Alcohol consumption and the risk for prostate cancer in the european prospective investigation into cancer and nutrition

Sabine Rohrmann, Jakob Linseisen, Timothy J. Key, Majken K. Jensen, Kim Overvad, Nina Føns Johnsen, Anne Tjønneland, Rudolf Kaaks, Manuela M. Bergmann, Cornelia Weikert, Androniki Naska, Antonia Trichopoulou, Dimitrios Trichopoulos, Valeria Pala, Carlotta Sacerdote, Domenico Palli, Rosario Tumino, H. Bas Bueno-de-Mesquita, Alina Vrieling, Carlos A. GonzálezNerea Larrañaga, Carmen Navarro, Aurelio Barricarte, J. Ramon Quiros, Carmen Martínez-García, Göran Hallmans, Pär Stattin, Jonas Manjer, Elisabet Wirfält, Sheila Bingham, Key Tee Khaw, Lars Egevad, Pietro Ferrari, Mazda Jenab, Elio Riboli

Research output: Contribution to journalArticle

Abstract

Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information were collected from 142,607 male participants on the intake of alcoholic beverages at recruitment (for 100% of the cohort) and over lifetime (for 76% of the cohort) between 1992 and 2000. During a median follow-up of 8.7 years, 2,655 prostate cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of alcohol consumption at recruitment and average lifetime alcohol consumption with prostate cancer adjusted for age, center, smoking, height, weight, physical activity, and nonalcohol energy intake. Overall, neither alcohol consumption at baseline nor average lifetime alcohol consumption was associated with the risk for prostate cancer in this cohort of men. Men who consumed ≥60 g alcohol per day had a relative risk of 0.88 [95% confidence interval (95% CI) 0.72-1.08] compared with men with an intake of 0.1-4.9 g/d; the respective relative risk for average lifetime intake was 1.09 (95% CI, 0.86-1.39). For advanced prostate cancer (n = 537), the relative risks for ≥60 and 0.1-4.9 g alcohol per day at baseline were 0.98 (95% CI, 0.66-1.44) and 1.28 (95% CI, 0.79-2-07), respectively, for average lifetime intake. No statistically significant association was observed for alcohol intake from specific alcoholic beverages. Our results indicate no association between the consumption of alcohol and prostate cancer in this cohort of European men.

Original languageEnglish
Pages (from-to)1282-1287
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume17
Issue number5
DOIs
Publication statusPublished - May 2008

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Alcohol Drinking
Prostatic Neoplasms
Alcohols
Confidence Intervals
Alcoholic Beverages
Neoplasms
Energy Intake
Proportional Hazards Models
Smoking
Exercise
Weights and Measures

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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Alcohol consumption and the risk for prostate cancer in the european prospective investigation into cancer and nutrition. / Rohrmann, Sabine; Linseisen, Jakob; Key, Timothy J.; Jensen, Majken K.; Overvad, Kim; Johnsen, Nina Føns; Tjønneland, Anne; Kaaks, Rudolf; Bergmann, Manuela M.; Weikert, Cornelia; Naska, Androniki; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Pala, Valeria; Sacerdote, Carlotta; Palli, Domenico; Tumino, Rosario; Bueno-de-Mesquita, H. Bas; Vrieling, Alina; González, Carlos A.; Larrañaga, Nerea; Navarro, Carmen; Barricarte, Aurelio; Quiros, J. Ramon; Martínez-García, Carmen; Hallmans, Göran; Stattin, Pär; Manjer, Jonas; Wirfält, Elisabet; Bingham, Sheila; Khaw, Key Tee; Egevad, Lars; Ferrari, Pietro; Jenab, Mazda; Riboli, Elio.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 17, No. 5, 05.2008, p. 1282-1287.

Research output: Contribution to journalArticle

Rohrmann, S, Linseisen, J, Key, TJ, Jensen, MK, Overvad, K, Johnsen, NF, Tjønneland, A, Kaaks, R, Bergmann, MM, Weikert, C, Naska, A, Trichopoulou, A, Trichopoulos, D, Pala, V, Sacerdote, C, Palli, D, Tumino, R, Bueno-de-Mesquita, HB, Vrieling, A, González, CA, Larrañaga, N, Navarro, C, Barricarte, A, Quiros, JR, Martínez-García, C, Hallmans, G, Stattin, P, Manjer, J, Wirfält, E, Bingham, S, Khaw, KT, Egevad, L, Ferrari, P, Jenab, M & Riboli, E 2008, 'Alcohol consumption and the risk for prostate cancer in the european prospective investigation into cancer and nutrition', Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 5, pp. 1282-1287. https://doi.org/10.1158/1055-9965.EPI-07-2888
Rohrmann, Sabine ; Linseisen, Jakob ; Key, Timothy J. ; Jensen, Majken K. ; Overvad, Kim ; Johnsen, Nina Føns ; Tjønneland, Anne ; Kaaks, Rudolf ; Bergmann, Manuela M. ; Weikert, Cornelia ; Naska, Androniki ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Pala, Valeria ; Sacerdote, Carlotta ; Palli, Domenico ; Tumino, Rosario ; Bueno-de-Mesquita, H. Bas ; Vrieling, Alina ; González, Carlos A. ; Larrañaga, Nerea ; Navarro, Carmen ; Barricarte, Aurelio ; Quiros, J. Ramon ; Martínez-García, Carmen ; Hallmans, Göran ; Stattin, Pär ; Manjer, Jonas ; Wirfält, Elisabet ; Bingham, Sheila ; Khaw, Key Tee ; Egevad, Lars ; Ferrari, Pietro ; Jenab, Mazda ; Riboli, Elio. / Alcohol consumption and the risk for prostate cancer in the european prospective investigation into cancer and nutrition. In: Cancer Epidemiology Biomarkers and Prevention. 2008 ; Vol. 17, No. 5. pp. 1282-1287.
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abstract = "Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information were collected from 142,607 male participants on the intake of alcoholic beverages at recruitment (for 100{\%} of the cohort) and over lifetime (for 76{\%} of the cohort) between 1992 and 2000. During a median follow-up of 8.7 years, 2,655 prostate cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of alcohol consumption at recruitment and average lifetime alcohol consumption with prostate cancer adjusted for age, center, smoking, height, weight, physical activity, and nonalcohol energy intake. Overall, neither alcohol consumption at baseline nor average lifetime alcohol consumption was associated with the risk for prostate cancer in this cohort of men. Men who consumed ≥60 g alcohol per day had a relative risk of 0.88 [95{\%} confidence interval (95{\%} CI) 0.72-1.08] compared with men with an intake of 0.1-4.9 g/d; the respective relative risk for average lifetime intake was 1.09 (95{\%} CI, 0.86-1.39). For advanced prostate cancer (n = 537), the relative risks for ≥60 and 0.1-4.9 g alcohol per day at baseline were 0.98 (95{\%} CI, 0.66-1.44) and 1.28 (95{\%} CI, 0.79-2-07), respectively, for average lifetime intake. No statistically significant association was observed for alcohol intake from specific alcoholic beverages. Our results indicate no association between the consumption of alcohol and prostate cancer in this cohort of European men.",
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T1 - Alcohol consumption and the risk for prostate cancer in the european prospective investigation into cancer and nutrition

AU - Rohrmann, Sabine

AU - Linseisen, Jakob

AU - Key, Timothy J.

AU - Jensen, Majken K.

AU - Overvad, Kim

AU - Johnsen, Nina Føns

AU - Tjønneland, Anne

AU - Kaaks, Rudolf

AU - Bergmann, Manuela M.

AU - Weikert, Cornelia

AU - Naska, Androniki

AU - Trichopoulou, Antonia

AU - Trichopoulos, Dimitrios

AU - Pala, Valeria

AU - Sacerdote, Carlotta

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Bueno-de-Mesquita, H. Bas

AU - Vrieling, Alina

AU - González, Carlos A.

AU - Larrañaga, Nerea

AU - Navarro, Carmen

AU - Barricarte, Aurelio

AU - Quiros, J. Ramon

AU - Martínez-García, Carmen

AU - Hallmans, Göran

AU - Stattin, Pär

AU - Manjer, Jonas

AU - Wirfält, Elisabet

AU - Bingham, Sheila

AU - Khaw, Key Tee

AU - Egevad, Lars

AU - Ferrari, Pietro

AU - Jenab, Mazda

AU - Riboli, Elio

PY - 2008/5

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N2 - Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information were collected from 142,607 male participants on the intake of alcoholic beverages at recruitment (for 100% of the cohort) and over lifetime (for 76% of the cohort) between 1992 and 2000. During a median follow-up of 8.7 years, 2,655 prostate cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of alcohol consumption at recruitment and average lifetime alcohol consumption with prostate cancer adjusted for age, center, smoking, height, weight, physical activity, and nonalcohol energy intake. Overall, neither alcohol consumption at baseline nor average lifetime alcohol consumption was associated with the risk for prostate cancer in this cohort of men. Men who consumed ≥60 g alcohol per day had a relative risk of 0.88 [95% confidence interval (95% CI) 0.72-1.08] compared with men with an intake of 0.1-4.9 g/d; the respective relative risk for average lifetime intake was 1.09 (95% CI, 0.86-1.39). For advanced prostate cancer (n = 537), the relative risks for ≥60 and 0.1-4.9 g alcohol per day at baseline were 0.98 (95% CI, 0.66-1.44) and 1.28 (95% CI, 0.79-2-07), respectively, for average lifetime intake. No statistically significant association was observed for alcohol intake from specific alcoholic beverages. Our results indicate no association between the consumption of alcohol and prostate cancer in this cohort of European men.

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