TY - JOUR
T1 - Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study
AU - IMPROVE study group
AU - Laguzzi, Federica
AU - Baldassarre, Damiano
AU - Veglia, Fabrizio
AU - Strawbridge, Rona J.
AU - Humphries, Steve E.
AU - Rauramaa, Rainer
AU - Smit, Andries J.
AU - Giral, Philippe
AU - Silveira, Angela
AU - Tremoli, Elena
AU - Hamsten, Anders
AU - de Faire, Ulf
AU - Frumento, Paolo
AU - Leander, Karin
AU - Sirtori, C. R.
AU - Castelnuovo, S.
AU - Amato, M.
AU - Frigerio, B.
AU - Ravani, A.
AU - Sansaro, D.
AU - Tedesco, C.
AU - Coggi, D.
AU - Bonomi, A.
AU - Eriksson, M. J.
AU - Cooper, J.
AU - Acharya, J.
AU - Huttunen, K.
AU - Rauramaa, E.
AU - Pekkarinen, H.
AU - Penttila, I. M.
AU - Törrönen, J.
AU - van Gessel, A. I.
AU - van Roon, A. M.
AU - Teune, G. C.
AU - Kuipers, W. D.
AU - Bruin, M.
AU - Nicolai, A.
AU - Haarsma-Jorritsma, P.
AU - Mulder, D. J.
AU - Bilo, H. J.G.
AU - Smeets, G. H.
AU - Beaudeux, J. L.
AU - Kahn, J. F.
AU - Carreau, V.
AU - Kontush, A.
AU - Karppi, J.
AU - Nurmi, T.
AU - Nyyssönen, K.
AU - Salonen, R.
AU - Tuomainen, T. P.
N1 - Funding Information:
This study was supported by the European Commission (Contract number: QLG1-CT-2002-00896), the Swedish Heart–Lung Foundation, the Swedish Research Council (project 8691 and 0593), the Swedish Foundation for Strategic Research, the Stockholm County Council (project 562183), and the British Heart Foundation (RG2008/008). RJS is supported by a UKRI Innovation-HDR-UK Fellowship (MR/S003061/1). Ackowledgements
Publisher Copyright:
© 2020, The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Background/Aim: The association between alcohol consumption and subclinical atherosclerosis is still unclear. Using data from a European multicentre study, we assess subclinical atherosclerosis and its 30-month progression by carotid intima-media thickness (C-IMT) measurements, and correlate this information with self-reported data on alcohol consumption. Methods: Between 2002–2004, 1772 men and 1931 women aged 54–79 years with at least three risk factors for cardiovascular disease (CVD) were recruited in Italy, France, Netherlands, Sweden, and Finland. Self-reported alcohol consumption, assessed at baseline, was categorized as follows: none (0 g/d), very-low (0 − 5 g/d), low (> 5 to ≤ 10 g/d), moderate (> 10 to ≤ 20 g/d for women, > 10 to ≤ 30 g/d for men) and high (> 20 g/d for women, > 30 g/d for men). C-IMT was measured in millimeters at baseline and after 30 months. Measurements consisted of the mean and maximum values of the common carotids (CC), internal carotid artery (ICA), and bifurcations (Bif) and whole carotid tree. We used quantile regression to describe the associations between C-IMT measures and alcohol consumption categories, adjusting for sex, age, physical activity, education, smoking, diet, and latitude. Results: Adjusted differences between median C-IMT values in different levels of alcohol consumption (vs. very-low) showed that moderate alcohol consumption was associated with lower C-IMTmax[− 0.17(95%CI − 0.32; − 0.02)], and Bif-IMTmean[− 0.07(95%CI − 0.13; − 0.01)] at baseline and decreasing C-IMTmean[− 0.006 (95%CI − 0.011; − 0.000)], Bif-IMTmean[− 0.016(95%CI − 0.027; − 0.005)], ICA-IMTmean[− 0.009(95% − 0.016; − 0.002)] and ICA-IMTmax[− 0.016(95%: − 0.032; − 0.000)] after 30 months. There was no evidence of departure from linearity in the association between alcohol consumption and C-IMT. Conclusion: In this European population at high risk of CVD, findings show an inverse relation between moderate alcohol consumption and carotid subclinical atherosclerosis and its 30-month progression, independently of several potential confounders.
AB - Background/Aim: The association between alcohol consumption and subclinical atherosclerosis is still unclear. Using data from a European multicentre study, we assess subclinical atherosclerosis and its 30-month progression by carotid intima-media thickness (C-IMT) measurements, and correlate this information with self-reported data on alcohol consumption. Methods: Between 2002–2004, 1772 men and 1931 women aged 54–79 years with at least three risk factors for cardiovascular disease (CVD) were recruited in Italy, France, Netherlands, Sweden, and Finland. Self-reported alcohol consumption, assessed at baseline, was categorized as follows: none (0 g/d), very-low (0 − 5 g/d), low (> 5 to ≤ 10 g/d), moderate (> 10 to ≤ 20 g/d for women, > 10 to ≤ 30 g/d for men) and high (> 20 g/d for women, > 30 g/d for men). C-IMT was measured in millimeters at baseline and after 30 months. Measurements consisted of the mean and maximum values of the common carotids (CC), internal carotid artery (ICA), and bifurcations (Bif) and whole carotid tree. We used quantile regression to describe the associations between C-IMT measures and alcohol consumption categories, adjusting for sex, age, physical activity, education, smoking, diet, and latitude. Results: Adjusted differences between median C-IMT values in different levels of alcohol consumption (vs. very-low) showed that moderate alcohol consumption was associated with lower C-IMTmax[− 0.17(95%CI − 0.32; − 0.02)], and Bif-IMTmean[− 0.07(95%CI − 0.13; − 0.01)] at baseline and decreasing C-IMTmean[− 0.006 (95%CI − 0.011; − 0.000)], Bif-IMTmean[− 0.016(95%CI − 0.027; − 0.005)], ICA-IMTmean[− 0.009(95% − 0.016; − 0.002)] and ICA-IMTmax[− 0.016(95%: − 0.032; − 0.000)] after 30 months. There was no evidence of departure from linearity in the association between alcohol consumption and C-IMT. Conclusion: In this European population at high risk of CVD, findings show an inverse relation between moderate alcohol consumption and carotid subclinical atherosclerosis and its 30-month progression, independently of several potential confounders.
KW - Alcohol drinking
KW - Atherosclerosis
KW - Carotid intima-media thickness
KW - Epidemiology
KW - Progression
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U2 - 10.1007/s00394-020-02220-5
DO - 10.1007/s00394-020-02220-5
M3 - Article
AN - SCOPUS:85082185657
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
ER -