TY - JOUR
T1 - Alcohol dehydrogenase 3, glutathione S-transferase M1 and T1 polymorphisms, alcohol consumption and hepatocellular carcinoma (Italy)
AU - Covolo, Loredana
AU - Gelatti, Umberto
AU - Talamini, Renato
AU - Garte, Seymour
AU - Trevisi, Paola
AU - Franceschi, Silvia
AU - Franceschini, Michela
AU - Barbone, Fabio
AU - Tagger, Alessandro
AU - Ribero, Maria Lisa
AU - Parrinello, Giovanni
AU - Donadon, Valter
AU - Nardi, Giuseppe
AU - Donato, Francesco
PY - 2005/9
Y1 - 2005/9
N2 - Objective: The aim of this study was to investigate the role of alcohol dehydrogenase type 3 (ADH3), glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms in modifying hepatocellular carcinoma (HCC) risk according to alcohol intake. Methods: A hospital-based case-control study was conducted in two areas of North Italy. Two-hundred cases hospitalized for HCC and 400 controls were recruited. Genotypes were determined using PCR and the PCR/restriction fragment length polymorphism-based method. Results: There was no association of the putative risk genotypes ADH31-1, GSTM1 null and GSTT1 null with HCC (odds ratio [OR], 0.8; 95% confidence interval [CI], 0.5-1.3; OR, 1.0; 95% CI, 0.6-1.5; OR, 0.8; 95% CI, 0.4-1.4, respectively). A steady increase in HCC risk with increasing alcohol intake, which did not vary according to ADH3 and GSTT1 genotypes, was observed. Nevertheless, the OR for HCC due to an alcohol intake of >100 g of ethanol per day increased in subjects with GSTM1 null genotype (OR, 8.5; 95% CI, 3.9-18.6) compared to GSTM1 non-null genotype (OR, 4.5; 95% CI, 2.0-10.0). Conclusions: ADH31-1 and GSTT1 null genotypes did not modify the risk of HCC due to alcohol intake whereas an influence of GSTM1 null genotype for high ethanol consumption was suggested.
AB - Objective: The aim of this study was to investigate the role of alcohol dehydrogenase type 3 (ADH3), glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms in modifying hepatocellular carcinoma (HCC) risk according to alcohol intake. Methods: A hospital-based case-control study was conducted in two areas of North Italy. Two-hundred cases hospitalized for HCC and 400 controls were recruited. Genotypes were determined using PCR and the PCR/restriction fragment length polymorphism-based method. Results: There was no association of the putative risk genotypes ADH31-1, GSTM1 null and GSTT1 null with HCC (odds ratio [OR], 0.8; 95% confidence interval [CI], 0.5-1.3; OR, 1.0; 95% CI, 0.6-1.5; OR, 0.8; 95% CI, 0.4-1.4, respectively). A steady increase in HCC risk with increasing alcohol intake, which did not vary according to ADH3 and GSTT1 genotypes, was observed. Nevertheless, the OR for HCC due to an alcohol intake of >100 g of ethanol per day increased in subjects with GSTM1 null genotype (OR, 8.5; 95% CI, 3.9-18.6) compared to GSTM1 non-null genotype (OR, 4.5; 95% CI, 2.0-10.0). Conclusions: ADH31-1 and GSTT1 null genotypes did not modify the risk of HCC due to alcohol intake whereas an influence of GSTM1 null genotype for high ethanol consumption was suggested.
KW - Case-control study
KW - Epidemiology
KW - Gene-environment interaction
KW - Liver cancer
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U2 - 10.1007/s10552-005-2302-2
DO - 10.1007/s10552-005-2302-2
M3 - Article
C2 - 16132793
AN - SCOPUS:23844489133
VL - 16
SP - 831
EP - 838
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 7
ER -