Alcohol dependence and serotonin transporter functional polymorphisms 5-HTTLPR and rs25531 in an Italian population

Esterina Pascale, Giampiero Ferraguti, Claudia Codazzo, Francesca Passarelli, Rosanna Mancinelli, Cristian Bonvicini, Sabina Maria Bruno, Marco Lucarelli, Mauro Ceccanti

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aims: The role of the serotonin transporter gene (SLC6A4) in alcohol dependence (AD) is still unclear. In this paper, we have evaluated the association of the SLC6A4 gene polymorphisms 5-HTTLPR and rs25531 in AD and assessed the polymorphic patterns both in alcoholics and in healthy people of an Italian population.Methods: Genotyping of the 5-HTTLPR (L/S) and rs25531 (A/G) polymorphisms of the SLC6A4 gene was performed on 403 alcoholics outpatients and 427 blood donors.Results: Comparing AD and control populations and taking into account statistical correction for multiple testing, we found no statistically significant differences for 5-HTTLPR (L/S) and rs25531 polymorphisms in terms of either genotypes or alleles frequencies. By univariate ANOVA, a statistically significant difference was found in the onset of AD: the mean age of onset resulted to be of 25.4 years in males in respect to 28.1 in females. In particular in males, the early AD onset was different, in a statistically significant manner, depending on the presence of at least one S or Lg allele (24.6 years) in respect to La homozygotes (27.5 years) (P = 0.03).Conclusions: These findings suggest that genetic factors contribute, together with gender and age, to the onset differences in alcohol-dependent phenotypes.

Original languageEnglish
Article numberagv014
Pages (from-to)259-265
Number of pages7
JournalAlcohol and Alcoholism
Volume50
Issue number3
DOIs
Publication statusPublished - Aug 25 2014

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Serotonin Plasma Membrane Transport Proteins
Polymorphism
Alcoholism
Alcohols
Population
Alcoholics
Age of Onset
Genes
Homozygote
Blood Donors
Gene Frequency
Analysis of variance (ANOVA)
Analysis of Variance
Outpatients
Alleles
Genotype
Blood
Phenotype
Testing

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Pascale, E., Ferraguti, G., Codazzo, C., Passarelli, F., Mancinelli, R., Bonvicini, C., ... Ceccanti, M. (2014). Alcohol dependence and serotonin transporter functional polymorphisms 5-HTTLPR and rs25531 in an Italian population. Alcohol and Alcoholism, 50(3), 259-265. [agv014]. https://doi.org/10.1093/alcalc/agv014

Alcohol dependence and serotonin transporter functional polymorphisms 5-HTTLPR and rs25531 in an Italian population. / Pascale, Esterina; Ferraguti, Giampiero; Codazzo, Claudia; Passarelli, Francesca; Mancinelli, Rosanna; Bonvicini, Cristian; Bruno, Sabina Maria; Lucarelli, Marco; Ceccanti, Mauro.

In: Alcohol and Alcoholism, Vol. 50, No. 3, agv014, 25.08.2014, p. 259-265.

Research output: Contribution to journalArticle

Pascale, E, Ferraguti, G, Codazzo, C, Passarelli, F, Mancinelli, R, Bonvicini, C, Bruno, SM, Lucarelli, M & Ceccanti, M 2014, 'Alcohol dependence and serotonin transporter functional polymorphisms 5-HTTLPR and rs25531 in an Italian population', Alcohol and Alcoholism, vol. 50, no. 3, agv014, pp. 259-265. https://doi.org/10.1093/alcalc/agv014
Pascale, Esterina ; Ferraguti, Giampiero ; Codazzo, Claudia ; Passarelli, Francesca ; Mancinelli, Rosanna ; Bonvicini, Cristian ; Bruno, Sabina Maria ; Lucarelli, Marco ; Ceccanti, Mauro. / Alcohol dependence and serotonin transporter functional polymorphisms 5-HTTLPR and rs25531 in an Italian population. In: Alcohol and Alcoholism. 2014 ; Vol. 50, No. 3. pp. 259-265.
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