Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Veronika Fedirko, Mazda Jenab, Sabina Rinaldi, Carine Biessy, Naomi E. Allen, Laure Dossus, N. Charlotte Onland-Moret, Madlen Schütze, Anne Tjønneland, Louise Hansen, Kim Overvad, Françoise Clavel-Chapelon, Nathalie Chabbert-Buffet, Rudolf Kaaks, Annekatrin Lukanova, Manuela M. Bergmann, Heiner Boeing, Antonia Trichopoulou, Erifili Oustoglou, Antonia BarbitsiotiCalogero Saieva, Giovanna Tagliabue, Rocco Galasso, Rosario Tumino, Carlotta Sacerdote, Petra H. Peeters, H. Bas Bueno-de-Mesquita, Elisabete Weiderpass, Inger Torhild Gram, Soledad Sanchez, Eric J. Duell, Esther Molina-Montes, Larraitz Arriola, Maria Dolores Chirlaque, Eva Ardanaz, Jonas Manjer, Eva Lundin, Annika Idahl, Kay Tee Khaw, Dora Romaguera-Bosch, Petra A. Wark, Teresa Norat, Isabelle Romieu

Research output: Contribution to journalArticle

Abstract

Purpose: Alcohol intake may adversely affect the concentrations of endogenous sex hormones, and thus increase the risk of endometrial cancer. However, epidemiologic studies have provided conflicting results. Therefore, we investigated the association between alcohol intake and endometrial cancer risk a large, multicenter, prospective study. Methods: From 1992 through 2010, 301,051 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were followed for incident endometrial cancer (n = 1382). Baseline alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. Results: The multivariable HRs (and 95% CIs) compared with light drinkers (0.1-6 g/d) were 1.03 (0.88-1.20) for 0 g of alcohol per day at baseline, 1.01 (0.86-1.17) for 6.1-12 g/d, 1.03 (0.87-1.22) for 12.1-24 g/d, 1.07 (0.87-1.38) for 24.1-36 g/d, and 0.85 (0.61-1.18) for more than 36 g/d (ptrend = 0.77). No association was observed among former drinkers (OR, 1.28; 95% CI, 0.98-1.68 compared with light drinkers). Null associations were also found between alcohol consumption at age 20 years, lifetime pattern of alcohol drinking, and baseline alcohol intake from specific alcoholic beverages and endometrial cancer risk. Conclusions: Our findings suggest no association between alcohol intake and endometrial cancer risk.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalAnnals of Epidemiology
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Cohort studies
  • Endometrial neoplasms
  • Ethanol
  • Western Europe

ASJC Scopus subject areas

  • Epidemiology

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    Fedirko, V., Jenab, M., Rinaldi, S., Biessy, C., Allen, N. E., Dossus, L., Onland-Moret, N. C., Schütze, M., Tjønneland, A., Hansen, L., Overvad, K., Clavel-Chapelon, F., Chabbert-Buffet, N., Kaaks, R., Lukanova, A., Bergmann, M. M., Boeing, H., Trichopoulou, A., Oustoglou, E., ... Romieu, I. (2013). Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Annals of Epidemiology, 23(2), 93-98. https://doi.org/10.1016/j.annepidem.2012.11.009