Abstract
Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is available on the risk associated with light alcohol drinking. To address this issue, we conducted a meta-analysis using two methods: (i) random-effects models with reconstruction of alcohol consumption categories and calculation of risk estimates associated with predefined consumption levels using Hamling method and (ii) random-effects meta-regression models. The PubMed database was searched for all case-control or cohort studies published in the English language on the association between alcohol consumption and risk of laryngeal cancer. Forty studies (38 case-control, 2 cohort) reporting on at least three levels of consumption were included. Overall, alcohol drinking versus non-drinking was associated with an approximately 2-fold increase in risk of laryngeal cancer (RR = 1.90; 95% CI: 1.59-2.28). While light alcohol drinking (≤1 drink/day) did not show any significant association with risk of laryngeal cancer (12 studies. RR = 0.88; 95% CI: 0.71-1.08), moderate drinking (>1 to
| Original language | English |
|---|---|
| Pages (from-to) | 802-810 |
| Number of pages | 9 |
| Journal | Oral Oncology |
| Volume | 46 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2010 |
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Keywords
- Alcohol
- Case-control
- Cohort
- Laryngeal cancer
- Meta-analysis
- Review
ASJC Scopus subject areas
- Oncology
- Oral Surgery
- Cancer Research
Cite this
Alcohol drinking and laryngeal cancer : Overall and dose-risk relation - A systematic review and meta-analysis. / Islami, Farhad; Tramacere, Irene; Rota, Matteo; Bagnardi, Vincenzo; Fedirko, Veronika; Scotti, Lorenza; Garavello, Werner; Jenab, Mazda; Corrao, Giovanni; Straif, Kurt; Negri, Eva; Boffetta, Paolo; La Vecchia, Carlo.
In: Oral Oncology, Vol. 46, No. 11, 11.2010, p. 802-810.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alcohol drinking and laryngeal cancer
T2 - Overall and dose-risk relation - A systematic review and meta-analysis
AU - Islami, Farhad
AU - Tramacere, Irene
AU - Rota, Matteo
AU - Bagnardi, Vincenzo
AU - Fedirko, Veronika
AU - Scotti, Lorenza
AU - Garavello, Werner
AU - Jenab, Mazda
AU - Corrao, Giovanni
AU - Straif, Kurt
AU - Negri, Eva
AU - Boffetta, Paolo
AU - La Vecchia, Carlo
PY - 2010/11
Y1 - 2010/11
N2 - Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is available on the risk associated with light alcohol drinking. To address this issue, we conducted a meta-analysis using two methods: (i) random-effects models with reconstruction of alcohol consumption categories and calculation of risk estimates associated with predefined consumption levels using Hamling method and (ii) random-effects meta-regression models. The PubMed database was searched for all case-control or cohort studies published in the English language on the association between alcohol consumption and risk of laryngeal cancer. Forty studies (38 case-control, 2 cohort) reporting on at least three levels of consumption were included. Overall, alcohol drinking versus non-drinking was associated with an approximately 2-fold increase in risk of laryngeal cancer (RR = 1.90; 95% CI: 1.59-2.28). While light alcohol drinking (≤1 drink/day) did not show any significant association with risk of laryngeal cancer (12 studies. RR = 0.88; 95% CI: 0.71-1.08), moderate drinking (>1 to
AB - Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is available on the risk associated with light alcohol drinking. To address this issue, we conducted a meta-analysis using two methods: (i) random-effects models with reconstruction of alcohol consumption categories and calculation of risk estimates associated with predefined consumption levels using Hamling method and (ii) random-effects meta-regression models. The PubMed database was searched for all case-control or cohort studies published in the English language on the association between alcohol consumption and risk of laryngeal cancer. Forty studies (38 case-control, 2 cohort) reporting on at least three levels of consumption were included. Overall, alcohol drinking versus non-drinking was associated with an approximately 2-fold increase in risk of laryngeal cancer (RR = 1.90; 95% CI: 1.59-2.28). While light alcohol drinking (≤1 drink/day) did not show any significant association with risk of laryngeal cancer (12 studies. RR = 0.88; 95% CI: 0.71-1.08), moderate drinking (>1 to
KW - Alcohol
KW - Case-control
KW - Cohort
KW - Laryngeal cancer
KW - Meta-analysis
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=78049295529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049295529&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2010.07.015
DO - 10.1016/j.oraloncology.2010.07.015
M3 - Article
C2 - 20833578
AN - SCOPUS:78049295529
VL - 46
SP - 802
EP - 810
JO - Oral Oncology
JF - Oral Oncology
SN - 1368-8375
IS - 11
ER -