Abstract
Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is available on the risk associated with light alcohol drinking. To address this issue, we conducted a meta-analysis using two methods: (i) random-effects models with reconstruction of alcohol consumption categories and calculation of risk estimates associated with predefined consumption levels using Hamling method and (ii) random-effects meta-regression models. The PubMed database was searched for all case-control or cohort studies published in the English language on the association between alcohol consumption and risk of laryngeal cancer. Forty studies (38 case-control, 2 cohort) reporting on at least three levels of consumption were included. Overall, alcohol drinking versus non-drinking was associated with an approximately 2-fold increase in risk of laryngeal cancer (RR = 1.90; 95% CI: 1.59-2.28). While light alcohol drinking (≤1 drink/day) did not show any significant association with risk of laryngeal cancer (12 studies. RR = 0.88; 95% CI: 0.71-1.08), moderate drinking (>1 to
Original language | English |
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Pages (from-to) | 802-810 |
Number of pages | 9 |
Journal | Oral Oncology |
Volume | 46 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2010 |
Keywords
- Alcohol
- Case-control
- Cohort
- Laryngeal cancer
- Meta-analysis
- Review
ASJC Scopus subject areas
- Oncology
- Oral Surgery
- Cancer Research