Alcohol drinking and laryngeal cancer: Overall and dose-risk relation - A systematic review and meta-analysis

Farhad Islami, Irene Tramacere, Matteo Rota, Vincenzo Bagnardi, Veronika Fedirko, Lorenza Scotti, Werner Garavello, Mazda Jenab, Giovanni Corrao, Kurt Straif, Eva Negri, Paolo Boffetta, Carlo La Vecchia

Research output: Contribution to journalArticle

Abstract

Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is available on the risk associated with light alcohol drinking. To address this issue, we conducted a meta-analysis using two methods: (i) random-effects models with reconstruction of alcohol consumption categories and calculation of risk estimates associated with predefined consumption levels using Hamling method and (ii) random-effects meta-regression models. The PubMed database was searched for all case-control or cohort studies published in the English language on the association between alcohol consumption and risk of laryngeal cancer. Forty studies (38 case-control, 2 cohort) reporting on at least three levels of consumption were included. Overall, alcohol drinking versus non-drinking was associated with an approximately 2-fold increase in risk of laryngeal cancer (RR = 1.90; 95% CI: 1.59-2.28). While light alcohol drinking (≤1 drink/day) did not show any significant association with risk of laryngeal cancer (12 studies. RR = 0.88; 95% CI: 0.71-1.08), moderate drinking (>1 to

Original languageEnglish
Pages (from-to)802-810
Number of pages9
JournalOral Oncology
Volume46
Issue number11
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Laryngeal Neoplasms
Alcohol Drinking
Meta-Analysis
Case-Control Studies
Light
PubMed
Drinking
Cohort Studies
Language
Databases

Keywords

  • Alcohol
  • Case-control
  • Cohort
  • Laryngeal cancer
  • Meta-analysis
  • Review

ASJC Scopus subject areas

  • Oncology
  • Oral Surgery
  • Cancer Research

Cite this

Alcohol drinking and laryngeal cancer : Overall and dose-risk relation - A systematic review and meta-analysis. / Islami, Farhad; Tramacere, Irene; Rota, Matteo; Bagnardi, Vincenzo; Fedirko, Veronika; Scotti, Lorenza; Garavello, Werner; Jenab, Mazda; Corrao, Giovanni; Straif, Kurt; Negri, Eva; Boffetta, Paolo; La Vecchia, Carlo.

In: Oral Oncology, Vol. 46, No. 11, 11.2010, p. 802-810.

Research output: Contribution to journalArticle

Islami, F, Tramacere, I, Rota, M, Bagnardi, V, Fedirko, V, Scotti, L, Garavello, W, Jenab, M, Corrao, G, Straif, K, Negri, E, Boffetta, P & La Vecchia, C 2010, 'Alcohol drinking and laryngeal cancer: Overall and dose-risk relation - A systematic review and meta-analysis', Oral Oncology, vol. 46, no. 11, pp. 802-810. https://doi.org/10.1016/j.oraloncology.2010.07.015
Islami, Farhad ; Tramacere, Irene ; Rota, Matteo ; Bagnardi, Vincenzo ; Fedirko, Veronika ; Scotti, Lorenza ; Garavello, Werner ; Jenab, Mazda ; Corrao, Giovanni ; Straif, Kurt ; Negri, Eva ; Boffetta, Paolo ; La Vecchia, Carlo. / Alcohol drinking and laryngeal cancer : Overall and dose-risk relation - A systematic review and meta-analysis. In: Oral Oncology. 2010 ; Vol. 46, No. 11. pp. 802-810.
@article{c06876514ac74a8285fa666d3014072d,
title = "Alcohol drinking and laryngeal cancer: Overall and dose-risk relation - A systematic review and meta-analysis",
abstract = "Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is available on the risk associated with light alcohol drinking. To address this issue, we conducted a meta-analysis using two methods: (i) random-effects models with reconstruction of alcohol consumption categories and calculation of risk estimates associated with predefined consumption levels using Hamling method and (ii) random-effects meta-regression models. The PubMed database was searched for all case-control or cohort studies published in the English language on the association between alcohol consumption and risk of laryngeal cancer. Forty studies (38 case-control, 2 cohort) reporting on at least three levels of consumption were included. Overall, alcohol drinking versus non-drinking was associated with an approximately 2-fold increase in risk of laryngeal cancer (RR = 1.90; 95{\%} CI: 1.59-2.28). While light alcohol drinking (≤1 drink/day) did not show any significant association with risk of laryngeal cancer (12 studies. RR = 0.88; 95{\%} CI: 0.71-1.08), moderate drinking (>1 to",
keywords = "Alcohol, Case-control, Cohort, Laryngeal cancer, Meta-analysis, Review",
author = "Farhad Islami and Irene Tramacere and Matteo Rota and Vincenzo Bagnardi and Veronika Fedirko and Lorenza Scotti and Werner Garavello and Mazda Jenab and Giovanni Corrao and Kurt Straif and Eva Negri and Paolo Boffetta and {La Vecchia}, Carlo",
year = "2010",
month = "11",
doi = "10.1016/j.oraloncology.2010.07.015",
language = "English",
volume = "46",
pages = "802--810",
journal = "Oral Oncology",
issn = "1368-8375",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Alcohol drinking and laryngeal cancer

T2 - Overall and dose-risk relation - A systematic review and meta-analysis

AU - Islami, Farhad

AU - Tramacere, Irene

AU - Rota, Matteo

AU - Bagnardi, Vincenzo

AU - Fedirko, Veronika

AU - Scotti, Lorenza

AU - Garavello, Werner

AU - Jenab, Mazda

AU - Corrao, Giovanni

AU - Straif, Kurt

AU - Negri, Eva

AU - Boffetta, Paolo

AU - La Vecchia, Carlo

PY - 2010/11

Y1 - 2010/11

N2 - Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is available on the risk associated with light alcohol drinking. To address this issue, we conducted a meta-analysis using two methods: (i) random-effects models with reconstruction of alcohol consumption categories and calculation of risk estimates associated with predefined consumption levels using Hamling method and (ii) random-effects meta-regression models. The PubMed database was searched for all case-control or cohort studies published in the English language on the association between alcohol consumption and risk of laryngeal cancer. Forty studies (38 case-control, 2 cohort) reporting on at least three levels of consumption were included. Overall, alcohol drinking versus non-drinking was associated with an approximately 2-fold increase in risk of laryngeal cancer (RR = 1.90; 95% CI: 1.59-2.28). While light alcohol drinking (≤1 drink/day) did not show any significant association with risk of laryngeal cancer (12 studies. RR = 0.88; 95% CI: 0.71-1.08), moderate drinking (>1 to

AB - Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is available on the risk associated with light alcohol drinking. To address this issue, we conducted a meta-analysis using two methods: (i) random-effects models with reconstruction of alcohol consumption categories and calculation of risk estimates associated with predefined consumption levels using Hamling method and (ii) random-effects meta-regression models. The PubMed database was searched for all case-control or cohort studies published in the English language on the association between alcohol consumption and risk of laryngeal cancer. Forty studies (38 case-control, 2 cohort) reporting on at least three levels of consumption were included. Overall, alcohol drinking versus non-drinking was associated with an approximately 2-fold increase in risk of laryngeal cancer (RR = 1.90; 95% CI: 1.59-2.28). While light alcohol drinking (≤1 drink/day) did not show any significant association with risk of laryngeal cancer (12 studies. RR = 0.88; 95% CI: 0.71-1.08), moderate drinking (>1 to

KW - Alcohol

KW - Case-control

KW - Cohort

KW - Laryngeal cancer

KW - Meta-analysis

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=78049295529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049295529&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2010.07.015

DO - 10.1016/j.oraloncology.2010.07.015

M3 - Article

C2 - 20833578

AN - SCOPUS:78049295529

VL - 46

SP - 802

EP - 810

JO - Oral Oncology

JF - Oral Oncology

SN - 1368-8375

IS - 11

ER -