Alcohol drinking and laryngeal cancer: Overall and dose-risk relation - A systematic review and meta-analysis

Farhad Islami; Irene Tramacere; Matteo Rota; Vincenzo Bagnardi; Veronika Fedirko; Lorenza Scotti; Werner Garavello; Mazda Jenab; Giovanni Corrao; Kurt Straif; Eva Negri; Paolo Boffetta; Carlo La Vecchia

doi:10.1016/j.oraloncology.2010.07.015

Alcohol drinking and laryngeal cancer: Overall and dose-risk relation - A systematic review and meta-analysis

Farhad Islami, Irene Tramacere, Matteo Rota, Vincenzo Bagnardi, Veronika Fedirko, Lorenza Scotti, Werner Garavello, Mazda Jenab, Giovanni Corrao, Kurt Straif, Eva Negri, Paolo Boffetta, Carlo La Vecchia

Research output: Contribution to journal › Article › peer-review

Abstract

Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is available on the risk associated with light alcohol drinking. To address this issue, we conducted a meta-analysis using two methods: (i) random-effects models with reconstruction of alcohol consumption categories and calculation of risk estimates associated with predefined consumption levels using Hamling method and (ii) random-effects meta-regression models. The PubMed database was searched for all case-control or cohort studies published in the English language on the association between alcohol consumption and risk of laryngeal cancer. Forty studies (38 case-control, 2 cohort) reporting on at least three levels of consumption were included. Overall, alcohol drinking versus non-drinking was associated with an approximately 2-fold increase in risk of laryngeal cancer (RR = 1.90; 95% CI: 1.59-2.28). While light alcohol drinking (≤1 drink/day) did not show any significant association with risk of laryngeal cancer (12 studies. RR = 0.88; 95% CI: 0.71-1.08), moderate drinking (>1 to

Original language	English
Pages (from-to)	802-810
Number of pages	9
Journal	Oral Oncology
Volume	46
Issue number	11
DOIs	https://doi.org/10.1016/j.oraloncology.2010.07.015
Publication status	Published - Nov 2010

Keywords

Alcohol
Case-control
Cohort
Laryngeal cancer
Meta-analysis
Review

ASJC Scopus subject areas

Oncology
Oral Surgery
Cancer Research

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10.1016/j.oraloncology.2010.07.015

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title = "Alcohol drinking and laryngeal cancer: Overall and dose-risk relation - A systematic review and meta-analysis",

abstract = "Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is available on the risk associated with light alcohol drinking. To address this issue, we conducted a meta-analysis using two methods: (i) random-effects models with reconstruction of alcohol consumption categories and calculation of risk estimates associated with predefined consumption levels using Hamling method and (ii) random-effects meta-regression models. The PubMed database was searched for all case-control or cohort studies published in the English language on the association between alcohol consumption and risk of laryngeal cancer. Forty studies (38 case-control, 2 cohort) reporting on at least three levels of consumption were included. Overall, alcohol drinking versus non-drinking was associated with an approximately 2-fold increase in risk of laryngeal cancer (RR = 1.90; 95% CI: 1.59-2.28). While light alcohol drinking (≤1 drink/day) did not show any significant association with risk of laryngeal cancer (12 studies. RR = 0.88; 95% CI: 0.71-1.08), moderate drinking (>1 to ",

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author = "Farhad Islami and Irene Tramacere and Matteo Rota and Vincenzo Bagnardi and Veronika Fedirko and Lorenza Scotti and Werner Garavello and Mazda Jenab and Giovanni Corrao and Kurt Straif and Eva Negri and Paolo Boffetta and {La Vecchia}, Carlo",

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AU - Fedirko, Veronika

AU - Scotti, Lorenza

AU - Garavello, Werner

AU - Jenab, Mazda

AU - Corrao, Giovanni

AU - Straif, Kurt

AU - Negri, Eva

AU - Boffetta, Paolo

AU - La Vecchia, Carlo

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Alcohol drinking and laryngeal cancer: Overall and dose-risk relation - A systematic review and meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

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