Alcohol drinking and laryngeal cancer: Overall and dose-risk relation - A systematic review and meta-analysis

Farhad Islami, Irene Tramacere, Matteo Rota, Vincenzo Bagnardi, Veronika Fedirko, Lorenza Scotti, Werner Garavello, Mazda Jenab, Giovanni Corrao, Kurt Straif, Eva Negri, Paolo Boffetta, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review


Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is available on the risk associated with light alcohol drinking. To address this issue, we conducted a meta-analysis using two methods: (i) random-effects models with reconstruction of alcohol consumption categories and calculation of risk estimates associated with predefined consumption levels using Hamling method and (ii) random-effects meta-regression models. The PubMed database was searched for all case-control or cohort studies published in the English language on the association between alcohol consumption and risk of laryngeal cancer. Forty studies (38 case-control, 2 cohort) reporting on at least three levels of consumption were included. Overall, alcohol drinking versus non-drinking was associated with an approximately 2-fold increase in risk of laryngeal cancer (RR = 1.90; 95% CI: 1.59-2.28). While light alcohol drinking (≤1 drink/day) did not show any significant association with risk of laryngeal cancer (12 studies. RR = 0.88; 95% CI: 0.71-1.08), moderate drinking (>1 to

Original languageEnglish
Pages (from-to)802-810
Number of pages9
JournalOral Oncology
Issue number11
Publication statusPublished - Nov 2010


  • Alcohol
  • Case-control
  • Cohort
  • Laryngeal cancer
  • Meta-analysis
  • Review

ASJC Scopus subject areas

  • Oncology
  • Oral Surgery
  • Cancer Research


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