Alcohol drinking and laryngeal cancer: Overall and dose-risk relation - A systematic review and meta-analysis

Farhad Islami; Irene Tramacere; Matteo Rota; Vincenzo Bagnardi; Veronika Fedirko; Lorenza Scotti; Werner Garavello; Mazda Jenab; Giovanni Corrao; Kurt Straif; Eva Negri; Paolo Boffetta; Carlo La Vecchia

doi:10.1016/j.oraloncology.2010.07.015

Alcohol drinking and laryngeal cancer: Overall and dose-risk relation - A systematic review and meta-analysis

Farhad Islami, Irene Tramacere, Matteo Rota, Vincenzo Bagnardi, Veronika Fedirko, Lorenza Scotti, Werner Garavello, Mazda Jenab, Giovanni Corrao, Kurt Straif, Eva Negri, Paolo Boffetta, Carlo La Vecchia

Research output: Contribution to journal › Article › peer-review

Abstract

Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is available on the risk associated with light alcohol drinking. To address this issue, we conducted a meta-analysis using two methods: (i) random-effects models with reconstruction of alcohol consumption categories and calculation of risk estimates associated with predefined consumption levels using Hamling method and (ii) random-effects meta-regression models. The PubMed database was searched for all case-control or cohort studies published in the English language on the association between alcohol consumption and risk of laryngeal cancer. Forty studies (38 case-control, 2 cohort) reporting on at least three levels of consumption were included. Overall, alcohol drinking versus non-drinking was associated with an approximately 2-fold increase in risk of laryngeal cancer (RR = 1.90; 95% CI: 1.59-2.28). While light alcohol drinking (≤1 drink/day) did not show any significant association with risk of laryngeal cancer (12 studies. RR = 0.88; 95% CI: 0.71-1.08), moderate drinking (>1 to

Original language	English
Pages (from-to)	802-810
Number of pages	9
Journal	Oral Oncology
Volume	46
Issue number	11
DOIs	https://doi.org/10.1016/j.oraloncology.2010.07.015
Publication status	Published - Nov 2010

Keywords

Alcohol
Case-control
Cohort
Laryngeal cancer
Meta-analysis
Review

ASJC Scopus subject areas

Oncology
Oral Surgery
Cancer Research

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Alcohol drinking and laryngeal cancer : Overall and dose-risk relation - A systematic review and meta-analysis. / Islami, Farhad; Tramacere, Irene; Rota, Matteo; Bagnardi, Vincenzo; Fedirko, Veronika; Scotti, Lorenza; Garavello, Werner; Jenab, Mazda; Corrao, Giovanni; Straif, Kurt; Negri, Eva; Boffetta, Paolo; La Vecchia, Carlo.

In: Oral Oncology, Vol. 46, No. 11, 11.2010, p. 802-810.

Research output: Contribution to journal › Article › peer-review

Islami, Farhad ; Tramacere, Irene ; Rota, Matteo ; Bagnardi, Vincenzo ; Fedirko, Veronika ; Scotti, Lorenza ; Garavello, Werner ; Jenab, Mazda ; Corrao, Giovanni ; Straif, Kurt ; Negri, Eva ; Boffetta, Paolo ; La Vecchia, Carlo. / Alcohol drinking and laryngeal cancer : Overall and dose-risk relation - A systematic review and meta-analysis. In: Oral Oncology. 2010 ; Vol. 46, No. 11. pp. 802-810.

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