Alcohol drinking outside meals and cancers of the upper aero-digestive tract

Luigino Dal Maso, Carlo La Vecchia, Jerry Polesel, Renato Talamini, Fabio Levi, Ettore Conti, Paola Zambon, Eva Negri, Silvia Franceschi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In our integrated series of case-control studies conducted in Italy and Switzerland (324 oral, 397 pharyngeal, 271 oesophageal, 506 laryngeal cancers and 3,263 controls), individuals who also drank alcoholic beverages outside meals showed an increased risk compared to those who drank at meals only. At any alcohol intake level, subjects also drinking between meals showed a more elevated risk of developing an upper aero-digestive tract cancer than subjects drinking only at meals. After adjustment for potential covariates, and, after allowance for the number of daily drinks to adjust for different alcohol-intake levels, the odds ratios for subjects reporting drinking outside meals were 1.5 (95% confidence interval [Cl]: 1.0-2.2) for oral, 1.8 (95% Cl: 1.3-2.5) for pharyngeal, 1.7 (95% Cl: 1.2-2.5) for oesophageal and 1.2 (95% Cl: 0.9-1.7) for laryngeal cancers. Our findings show that drinking pattern with respect to food consumption may influence alcohol carcinogenesis in the upper digestive and respiratory tract. An "alcohol washing effect" by chewing and swallowing is suggested.

Original languageEnglish
Pages (from-to)435-437
Number of pages3
JournalInternational Journal of Cancer
Volume102
Issue number4
DOIs
Publication statusPublished - Dec 1 2002

Fingerprint

Alcohol Drinking
Meals
Gastrointestinal Tract
Drinking
Alcohols
Laryngeal Neoplasms
Neoplasms
Alcoholic Beverages
Mastication
Deglutition
Switzerland
Respiratory System
Italy
Case-Control Studies
Carcinogenesis
Odds Ratio
Confidence Intervals
Food

Keywords

  • Aero-digestive tract cancer
  • Alcohol
  • Case-control study
  • Meals

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Alcohol drinking outside meals and cancers of the upper aero-digestive tract. / Maso, Luigino Dal; Vecchia, Carlo La; Polesel, Jerry; Talamini, Renato; Levi, Fabio; Conti, Ettore; Zambon, Paola; Negri, Eva; Franceschi, Silvia.

In: International Journal of Cancer, Vol. 102, No. 4, 01.12.2002, p. 435-437.

Research output: Contribution to journalArticle

Maso, LD, Vecchia, CL, Polesel, J, Talamini, R, Levi, F, Conti, E, Zambon, P, Negri, E & Franceschi, S 2002, 'Alcohol drinking outside meals and cancers of the upper aero-digestive tract', International Journal of Cancer, vol. 102, no. 4, pp. 435-437. https://doi.org/10.1002/ijc.10723
Maso, Luigino Dal ; Vecchia, Carlo La ; Polesel, Jerry ; Talamini, Renato ; Levi, Fabio ; Conti, Ettore ; Zambon, Paola ; Negri, Eva ; Franceschi, Silvia. / Alcohol drinking outside meals and cancers of the upper aero-digestive tract. In: International Journal of Cancer. 2002 ; Vol. 102, No. 4. pp. 435-437.
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