Abstract
Brain activity during resting wakefulness is characterized by slow (<0.1. Hz) fluctuations of blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals that are topographically organized in discrete functional connectivity networks (resting-state networks, RSNs). The present study aimed at revealing possible network-specific alcohol-induced changes in resting-state fMRI (RS-fMRI) signals. RS-fMRI was carried out on eight healthy subjects in four consecutive 6-min sessions, one before and three after a 0.7. g/kg dose of ethyl alcohol. Control experiments were carried out in different days without alcohol administration. Independent component analysis (ICA) was performed on all experimental and control scans to extract individual and group-level RSN maps in a dynamic network analysis.Alcohol administration significantly increased the overall strength of the visual network ICA component, reaching the peak at 90. min. Within the visual network, the alcohol-induced increase was more pronounced in the primary regions of the occipital cortex and less pronounced in the secondary regions of the occipito-temporal cortex. Other major RSN components, such as the default-mode, the fronto-parietal, the sensori-motor, the self-referential and the auditory components, did not exhibit alcohol-induced changes during the same time window. Alcohol-induced effects on the resting-state functional connectivity of the visual network observed in the present study demonstrate that the visual system is a selective and primary target of acute alcohol administration. The strong enhancement of spontaneous BOLD fluctuations in the primary visual cortex in an acute alcoholic state may impair the normal activation response to visual stimuli and affect visual perception.
| Original language | English |
|---|---|
| Pages (from-to) | 534-543 |
| Number of pages | 10 |
| Journal | NeuroImage |
| Volume | 53 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Nov 2010 |
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Keywords
- FMRI
- Functional magnetic resonance imaging
- Independent component analysis
- Resting state
- Visual function
- Visual network
- Visual perception
ASJC Scopus subject areas
- Cognitive Neuroscience
- Neurology
Cite this
Alcohol increases spontaneous BOLD signal fluctuations in the visual network. / Esposito, Fabrizio; Pignataro, Giuseppe; Di Renzo, Gianfranco; Spinali, Alessandra; Paccone, Antonella; Tedeschi, Gioacchino; Annunziato, Lucio.
In: NeuroImage, Vol. 53, No. 2, 11.2010, p. 534-543.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alcohol increases spontaneous BOLD signal fluctuations in the visual network
AU - Esposito, Fabrizio
AU - Pignataro, Giuseppe
AU - Di Renzo, Gianfranco
AU - Spinali, Alessandra
AU - Paccone, Antonella
AU - Tedeschi, Gioacchino
AU - Annunziato, Lucio
PY - 2010/11
Y1 - 2010/11
N2 - Brain activity during resting wakefulness is characterized by slow (<0.1. Hz) fluctuations of blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals that are topographically organized in discrete functional connectivity networks (resting-state networks, RSNs). The present study aimed at revealing possible network-specific alcohol-induced changes in resting-state fMRI (RS-fMRI) signals. RS-fMRI was carried out on eight healthy subjects in four consecutive 6-min sessions, one before and three after a 0.7. g/kg dose of ethyl alcohol. Control experiments were carried out in different days without alcohol administration. Independent component analysis (ICA) was performed on all experimental and control scans to extract individual and group-level RSN maps in a dynamic network analysis.Alcohol administration significantly increased the overall strength of the visual network ICA component, reaching the peak at 90. min. Within the visual network, the alcohol-induced increase was more pronounced in the primary regions of the occipital cortex and less pronounced in the secondary regions of the occipito-temporal cortex. Other major RSN components, such as the default-mode, the fronto-parietal, the sensori-motor, the self-referential and the auditory components, did not exhibit alcohol-induced changes during the same time window. Alcohol-induced effects on the resting-state functional connectivity of the visual network observed in the present study demonstrate that the visual system is a selective and primary target of acute alcohol administration. The strong enhancement of spontaneous BOLD fluctuations in the primary visual cortex in an acute alcoholic state may impair the normal activation response to visual stimuli and affect visual perception.
AB - Brain activity during resting wakefulness is characterized by slow (<0.1. Hz) fluctuations of blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals that are topographically organized in discrete functional connectivity networks (resting-state networks, RSNs). The present study aimed at revealing possible network-specific alcohol-induced changes in resting-state fMRI (RS-fMRI) signals. RS-fMRI was carried out on eight healthy subjects in four consecutive 6-min sessions, one before and three after a 0.7. g/kg dose of ethyl alcohol. Control experiments were carried out in different days without alcohol administration. Independent component analysis (ICA) was performed on all experimental and control scans to extract individual and group-level RSN maps in a dynamic network analysis.Alcohol administration significantly increased the overall strength of the visual network ICA component, reaching the peak at 90. min. Within the visual network, the alcohol-induced increase was more pronounced in the primary regions of the occipital cortex and less pronounced in the secondary regions of the occipito-temporal cortex. Other major RSN components, such as the default-mode, the fronto-parietal, the sensori-motor, the self-referential and the auditory components, did not exhibit alcohol-induced changes during the same time window. Alcohol-induced effects on the resting-state functional connectivity of the visual network observed in the present study demonstrate that the visual system is a selective and primary target of acute alcohol administration. The strong enhancement of spontaneous BOLD fluctuations in the primary visual cortex in an acute alcoholic state may impair the normal activation response to visual stimuli and affect visual perception.
KW - FMRI
KW - Functional magnetic resonance imaging
KW - Independent component analysis
KW - Resting state
KW - Visual function
KW - Visual network
KW - Visual perception
UR - http://www.scopus.com/inward/record.url?scp=77956059010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956059010&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2010.06.061
DO - 10.1016/j.neuroimage.2010.06.061
M3 - Article
C2 - 20600963
AN - SCOPUS:77956059010
VL - 53
SP - 534
EP - 543
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 2
ER -