Abstract
Cardiovascular disease represents the major cause of morbidity and mortality in patients with diabetes mellitus. The impact of cardiac disease includes increased sensitivity of diabetic myocardium to ischemic episodes and diabetic cardiomyopathy, manifested as a subnormal functional response of the diabetic heart independent of coronary artery disease. In this context, we were to our knowledge the first to demonstrate that diabetes increases glucose flux via the first and key enzyme, aldose reductase, of the polyol pathway, resulting in impaired glycolysis under normoxic and ischemic conditions in diabetic myocardium. Our laboratory has been investigating the role of the polyol pathway in mediating myocardial ischemic injury in diabetics. Furthermore, the influence of the aldose reductase pathway in facilitating generation of key potent glycating compounds has led us to investigate the impact of advanced glycation end products (AGEs) in myocardial ischemic injury in diabetics. The potent impact of increased flux via the aldose reductase pathway and the increased AGE interactions with its receptor (RAGE) resulting in cardiac dysfunction will be discussed in this chapter.
| Original language | English |
|---|---|
| Pages (from-to) | 702-709 |
| Number of pages | 8 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1043 |
| DOIs | |
| Publication status | Published - 2005 |
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Keywords
- AGEs
- Aldose reductase
- Ischemia reperfusion injury
- Myocardial ischemia
- Polyol pathway
- RAGE
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Cite this
Aldose reductase and AGE-RAGE pathways : Key players in myocardial ischemic injury. / Kaneko, Michiyo; Bucciarelli, Loredana; Hwang, Yuying C.; Lee, Larisee; Yan, Shi Fang; Schmidt, Ann Marie; Ramasamy, Ravichandran.
In: Annals of the New York Academy of Sciences, Vol. 1043, 2005, p. 702-709.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aldose reductase and AGE-RAGE pathways
T2 - Key players in myocardial ischemic injury
AU - Kaneko, Michiyo
AU - Bucciarelli, Loredana
AU - Hwang, Yuying C.
AU - Lee, Larisee
AU - Yan, Shi Fang
AU - Schmidt, Ann Marie
AU - Ramasamy, Ravichandran
PY - 2005
Y1 - 2005
N2 - Cardiovascular disease represents the major cause of morbidity and mortality in patients with diabetes mellitus. The impact of cardiac disease includes increased sensitivity of diabetic myocardium to ischemic episodes and diabetic cardiomyopathy, manifested as a subnormal functional response of the diabetic heart independent of coronary artery disease. In this context, we were to our knowledge the first to demonstrate that diabetes increases glucose flux via the first and key enzyme, aldose reductase, of the polyol pathway, resulting in impaired glycolysis under normoxic and ischemic conditions in diabetic myocardium. Our laboratory has been investigating the role of the polyol pathway in mediating myocardial ischemic injury in diabetics. Furthermore, the influence of the aldose reductase pathway in facilitating generation of key potent glycating compounds has led us to investigate the impact of advanced glycation end products (AGEs) in myocardial ischemic injury in diabetics. The potent impact of increased flux via the aldose reductase pathway and the increased AGE interactions with its receptor (RAGE) resulting in cardiac dysfunction will be discussed in this chapter.
AB - Cardiovascular disease represents the major cause of morbidity and mortality in patients with diabetes mellitus. The impact of cardiac disease includes increased sensitivity of diabetic myocardium to ischemic episodes and diabetic cardiomyopathy, manifested as a subnormal functional response of the diabetic heart independent of coronary artery disease. In this context, we were to our knowledge the first to demonstrate that diabetes increases glucose flux via the first and key enzyme, aldose reductase, of the polyol pathway, resulting in impaired glycolysis under normoxic and ischemic conditions in diabetic myocardium. Our laboratory has been investigating the role of the polyol pathway in mediating myocardial ischemic injury in diabetics. Furthermore, the influence of the aldose reductase pathway in facilitating generation of key potent glycating compounds has led us to investigate the impact of advanced glycation end products (AGEs) in myocardial ischemic injury in diabetics. The potent impact of increased flux via the aldose reductase pathway and the increased AGE interactions with its receptor (RAGE) resulting in cardiac dysfunction will be discussed in this chapter.
KW - AGEs
KW - Aldose reductase
KW - Ischemia reperfusion injury
KW - Myocardial ischemia
KW - Polyol pathway
KW - RAGE
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U2 - 10.1196/annals.1333.081
DO - 10.1196/annals.1333.081
M3 - Article
VL - 1043
SP - 702
EP - 709
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -