Aldosterone synthase alleles and cardiovascular phenotype in young adults

R. Sarzani, F. Salvi, P. Dessí-Fulgheri, R. Catalini, D. Mazzara, G. Cola, N. Siragusa, D. Spagnolo, P. Ercolani, R. Gesuita, F. Carle, A. Rappelli

Research output: Contribution to journalArticle

Abstract

The C(-344)T promoter polymorphism of the human aldosterone synthase (CYP11B2) gene has been associated with hypertension and cardiac hypertrophy, but there were contrasting data. We analysed the genotype/phenotype associations between this polymorphism and cardiovascular variables in a young adult population, where interactions among genes, gene-environment, and acquired ageing-related organ damage are reduced. Anthropometric measurements, blood pressure, heart rate, left ventricular variables (by echocardiography), and carotid artery wall intimal-media thickness (by high-resolution sonography and digitalized morphometry) were taken in 420 white Caucasian students (mean age 23.5 years, s.d. 2.5 years). CYP11B2 alleles were detected by genomic polymerase chain reaction followed by digestion. Taking into account the three possible models of inheritance, we found no differences in the considered variables, except for an independent effect of the C(-344) allele on SBP in males (TT 125.6 (1.6), TC 128.4 (1.2) and CC 130.5 (2.2), mmHg, media (ES), P=0.03), and on interventricular septum thickness in diastole in females (CC 6.98 (0.12) vs TT 6.87 (0.09) and TC 6.87 (0.07), mmHg, P

Original languageEnglish
Pages (from-to)859-864
Number of pages6
JournalJournal of Human Hypertension
Volume17
Issue number12
DOIs
Publication statusPublished - Dec 2003

Keywords

  • Aldosterone synthase
  • Alleles
  • Blood pressure
  • Cardiac hypertrophy
  • Young

ASJC Scopus subject areas

  • Internal Medicine

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    Sarzani, R., Salvi, F., Dessí-Fulgheri, P., Catalini, R., Mazzara, D., Cola, G., Siragusa, N., Spagnolo, D., Ercolani, P., Gesuita, R., Carle, F., & Rappelli, A. (2003). Aldosterone synthase alleles and cardiovascular phenotype in young adults. Journal of Human Hypertension, 17(12), 859-864. https://doi.org/10.1038/sj.jhh.1001619