TRATTAMENTO DELL'ACNE VOLGARE MEDIANTE APPLICAZIONI LOCALI DI ALGESTONE ACETOFENIDE

Translated title of the contribution: Algestone acetofenide and topical treatment of acne vulgaris

C. Occella, O. Nemelka, L. Schiazza

Research output: Contribution to journalArticle

Abstract

The role of androgens in acne vulgaris is well established; these steroids, in fact, highly stimulate the sebaceous glands. In this mechanism, a key function is performed by 5α-hidroxy-steroid reductase, an enzyme which transforms the blood borne testosterone in 5α-dihydrotestosterone, the active target hormone. Hormonal treatment of acne vulgaris is therefore possible through inhibition of the 5α reductase by suitable steroid molecules (progesterone, androstenedione, deoxycorticosterone, etc.) Among these steroids, progesterone is the most active and is a safe substrate. The authors, therefore, have performed a clinical and metabolic study in acne patients to compare progesterone activity with that of its derivative dihydroxyprogesterone acetophenide, (algestone acetophenide). After 40 days of dihydroxyprogesterone acetophenide on the interscapular region of two volunteers, the biochemical analysis showed a remarkable inhibition of the 5α reduction of testosterone. The clinical trial on 31 patients showed at its completion that the 8 patients affected by acne vulgaris were all cured, while a high percentage (11/23) of the 23 patients affected by pustular acne were cured or highly improved. No adverse reactions locally or in general have been observed.

Original languageItalian
Pages (from-to)76-82
Number of pages7
JournalGaslini
Volume13
Issue number1
Publication statusPublished - 1981

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Algestone
Algestone Acetophenide
Acne Vulgaris
Steroids
Progesterone
Testosterone
Oxidoreductases
Therapeutics
Sebaceous Glands
Desoxycorticosterone
Androstenedione
Dihydrotestosterone
Androgens
Volunteers
Clinical Trials
Hormones
Enzymes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

TRATTAMENTO DELL'ACNE VOLGARE MEDIANTE APPLICAZIONI LOCALI DI ALGESTONE ACETOFENIDE. / Occella, C.; Nemelka, O.; Schiazza, L.

In: Gaslini, Vol. 13, No. 1, 1981, p. 76-82.

Research output: Contribution to journalArticle

Occella, C. ; Nemelka, O. ; Schiazza, L. / TRATTAMENTO DELL'ACNE VOLGARE MEDIANTE APPLICAZIONI LOCALI DI ALGESTONE ACETOFENIDE. In: Gaslini. 1981 ; Vol. 13, No. 1. pp. 76-82.
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