Abstract
The role of androgens in acne vulgaris is well established; these steroids, in fact, highly stimulate the sebaceous glands. In this mechanism, a key function is performed by 5α-hidroxy-steroid reductase, an enzyme which transforms the blood borne testosterone in 5α-dihydrotestosterone, the active target hormone. Hormonal treatment of acne vulgaris is therefore possible through inhibition of the 5α reductase by suitable steroid molecules (progesterone, androstenedione, deoxycorticosterone, etc.) Among these steroids, progesterone is the most active and is a safe substrate. The authors, therefore, have performed a clinical and metabolic study in acne patients to compare progesterone activity with that of its derivative dihydroxyprogesterone acetophenide, (algestone acetophenide). After 40 days of dihydroxyprogesterone acetophenide on the interscapular region of two volunteers, the biochemical analysis showed a remarkable inhibition of the 5α reduction of testosterone. The clinical trial on 31 patients showed at its completion that the 8 patients affected by acne vulgaris were all cured, while a high percentage (11/23) of the 23 patients affected by pustular acne were cured or highly improved. No adverse reactions locally or in general have been observed.
| Original language | Italian |
|---|---|
| Pages (from-to) | 76-82 |
| Number of pages | 7 |
| Journal | Gaslini |
| Volume | 13 |
| Issue number | 1 |
| Publication status | Published - 1981 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
TRATTAMENTO DELL'ACNE VOLGARE MEDIANTE APPLICAZIONI LOCALI DI ALGESTONE ACETOFENIDE. / Occella, C.; Nemelka, O.; Schiazza, L.
In: Gaslini, Vol. 13, No. 1, 1981, p. 76-82.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - TRATTAMENTO DELL'ACNE VOLGARE MEDIANTE APPLICAZIONI LOCALI DI ALGESTONE ACETOFENIDE
AU - Occella, C.
AU - Nemelka, O.
AU - Schiazza, L.
PY - 1981
Y1 - 1981
N2 - The role of androgens in acne vulgaris is well established; these steroids, in fact, highly stimulate the sebaceous glands. In this mechanism, a key function is performed by 5α-hidroxy-steroid reductase, an enzyme which transforms the blood borne testosterone in 5α-dihydrotestosterone, the active target hormone. Hormonal treatment of acne vulgaris is therefore possible through inhibition of the 5α reductase by suitable steroid molecules (progesterone, androstenedione, deoxycorticosterone, etc.) Among these steroids, progesterone is the most active and is a safe substrate. The authors, therefore, have performed a clinical and metabolic study in acne patients to compare progesterone activity with that of its derivative dihydroxyprogesterone acetophenide, (algestone acetophenide). After 40 days of dihydroxyprogesterone acetophenide on the interscapular region of two volunteers, the biochemical analysis showed a remarkable inhibition of the 5α reduction of testosterone. The clinical trial on 31 patients showed at its completion that the 8 patients affected by acne vulgaris were all cured, while a high percentage (11/23) of the 23 patients affected by pustular acne were cured or highly improved. No adverse reactions locally or in general have been observed.
AB - The role of androgens in acne vulgaris is well established; these steroids, in fact, highly stimulate the sebaceous glands. In this mechanism, a key function is performed by 5α-hidroxy-steroid reductase, an enzyme which transforms the blood borne testosterone in 5α-dihydrotestosterone, the active target hormone. Hormonal treatment of acne vulgaris is therefore possible through inhibition of the 5α reductase by suitable steroid molecules (progesterone, androstenedione, deoxycorticosterone, etc.) Among these steroids, progesterone is the most active and is a safe substrate. The authors, therefore, have performed a clinical and metabolic study in acne patients to compare progesterone activity with that of its derivative dihydroxyprogesterone acetophenide, (algestone acetophenide). After 40 days of dihydroxyprogesterone acetophenide on the interscapular region of two volunteers, the biochemical analysis showed a remarkable inhibition of the 5α reduction of testosterone. The clinical trial on 31 patients showed at its completion that the 8 patients affected by acne vulgaris were all cured, while a high percentage (11/23) of the 23 patients affected by pustular acne were cured or highly improved. No adverse reactions locally or in general have been observed.
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M3 - Articolo
AN - SCOPUS:0019864025
VL - 13
SP - 76
EP - 82
JO - Gaslini
JF - Gaslini
SN - 0390-5845
IS - 1
ER -