Algo-dysfunctional syndromes: A critical digest of the recent literature

Rossella Talotta, Fabiola Atzeni, Laura Bazzichi, Camillo Giacomelli, Manuela Di Franco, Fausto Salaffi, Piercarlo Sarzi-Puttini

Research output: Contribution to journalArticle


The etiopathogenesis of the algo-dysfunctional syndromes, which include chronic fatigue syndrome, fibromyalgia and irritable bowel syndrome, is still debated, but it is widely accepted that it is best described by a multifactorial model that include genes, environmental factors such as external infections, inflammation, dietary habits, impaired endogenous cortisol production, the aberrant activation of some areas of the central nervous system, and small peripheral nervous fibre damage. This complexity suggests that they should be managed by means of a multidisciplinary approach involving the use of both pharmacological and non-pharmacological treatments. The aim of this review is to discuss the most recent scientific acquisitions concerning these syndromes and their treatment.

Original languageEnglish
Pages (from-to)S102-S108
JournalClinical and Experimental Rheumatology
Publication statusPublished - 2015



  • Chronic fatigue syndrome
  • Fibromyalgia
  • Irritable bowel syndrome

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Talotta, R., Atzeni, F., Bazzichi, L., Giacomelli, C., Di Franco, M., Salaffi, F., & Sarzi-Puttini, P. (2015). Algo-dysfunctional syndromes: A critical digest of the recent literature. Clinical and Experimental Rheumatology, 33, S102-S108.