Alix and ALG-2 make a link between endosomes and neuronal death

Anne Laure Mahul-Mellier, Flavie Strappazzon, Christine Chatellard-Causse, Béatrice Blot, David Béal, Sakina Torch, Fiona Hemming, Anne Petiot, Jean Marc Verna, Sandrine Fraboulet, Rémy Sadoul

Research output: Contribution to journalArticlepeer-review

Abstract

Alix [ALG-2 (apoptosis-linked gene 2)-interacting protein X] is a ubiquitinous adaptor protein first described for its capacity to bind to the calcium-binding protein, ALG-2. Alix regulates neuronal death in ways involving interactions with ALG-2 and with proteins of the ESCRT (endosomal sorting complex required for transport). Even though all Alix interactors characterized to date are involved in endosomal trafficking, the genuine function of the protein in this process remains unclear. We have demonstrated recently that Alix and ALG-2 form in the presence of calcium, a complex with apical caspases and with the endocytosed death receptor TNFR1 (tumour necrosis factor a receptor 1), thus suggesting a molecular coupling between endosomes and the cell death machinery.

Original languageEnglish
Pages (from-to)200-203
Number of pages4
JournalBiochemical Society Transactions
Volume37
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • Apoptosis
  • Calcium
  • Caspase
  • Endosomal sorting complex required for transport (ESCRT)
  • Neuron
  • Tumour necrosis factor α receptor 1 (TNFR1)

ASJC Scopus subject areas

  • Biochemistry

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