ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5

Stefano Fratoni, Pasquale Niscola, Xiangfeng Frank Zhao, Luigi Maria Larocca, Anna Capalbo, Maria Fabbretti, Laura Bernardini, Elisabetta Abruzzese

Research output: Contribution to journalArticle


Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.

Original languageEnglish
Article number152724
JournalPathology Research and Practice
Issue number2
Publication statusPublished - Feb 2020



  • ALK-negative anaplastic large cell lymphoma
  • PAX5
  • “Hodgkin-like” features

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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