ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5

Stefano Fratoni, Pasquale Niscola, Xiangfeng Frank Zhao, Luigi Maria Larocca, Anna Capalbo, Maria Fabbretti, Laura Bernardini, Elisabetta Abruzzese

Research output: Contribution to journalArticle

Abstract

Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.

Original languageEnglish
Article number152724
JournalPathology Research and Practice
Volume216
Issue number2
DOIs
Publication statusPublished - Feb 2020

Fingerprint

Anaplastic Large-Cell Lymphoma
T-Cell Lymphoma
Hodgkin Disease
Lymphoma
Lymph Nodes
Neoplasms
anaplastic lymphoma kinase

Keywords

  • ALK-negative anaplastic large cell lymphoma
  • PAX5
  • “Hodgkin-like” features

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5. / Fratoni, Stefano; Niscola, Pasquale; Zhao, Xiangfeng Frank; Larocca, Luigi Maria; Capalbo, Anna; Fabbretti, Maria; Bernardini, Laura; Abruzzese, Elisabetta.

In: Pathology Research and Practice, Vol. 216, No. 2, 152724, 02.2020.

Research output: Contribution to journalArticle

Fratoni, Stefano ; Niscola, Pasquale ; Zhao, Xiangfeng Frank ; Larocca, Luigi Maria ; Capalbo, Anna ; Fabbretti, Maria ; Bernardini, Laura ; Abruzzese, Elisabetta. / ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5. In: Pathology Research and Practice. 2020 ; Vol. 216, No. 2.
@article{0ab3b194a8ef4908a16e215854b26c6b,
title = "ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5",
abstract = "Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.",
keywords = "ALK-negative anaplastic large cell lymphoma, PAX5, “Hodgkin-like” features",
author = "Stefano Fratoni and Pasquale Niscola and Zhao, {Xiangfeng Frank} and Larocca, {Luigi Maria} and Anna Capalbo and Maria Fabbretti and Laura Bernardini and Elisabetta Abruzzese",
year = "2020",
month = "2",
doi = "10.1016/j.prp.2019.152724",
language = "English",
volume = "216",
journal = "Pathology Research and Practice",
issn = "0344-0338",
publisher = "Elsevier GmbH",
number = "2",

}

TY - JOUR

T1 - ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5

AU - Fratoni, Stefano

AU - Niscola, Pasquale

AU - Zhao, Xiangfeng Frank

AU - Larocca, Luigi Maria

AU - Capalbo, Anna

AU - Fabbretti, Maria

AU - Bernardini, Laura

AU - Abruzzese, Elisabetta

PY - 2020/2

Y1 - 2020/2

N2 - Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.

AB - Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.

KW - ALK-negative anaplastic large cell lymphoma

KW - PAX5

KW - “Hodgkin-like” features

UR - http://www.scopus.com/inward/record.url?scp=85078552392&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85078552392&partnerID=8YFLogxK

U2 - 10.1016/j.prp.2019.152724

DO - 10.1016/j.prp.2019.152724

M3 - Article

C2 - 31784094

AN - SCOPUS:85078552392

VL - 216

JO - Pathology Research and Practice

JF - Pathology Research and Practice

SN - 0344-0338

IS - 2

M1 - 152724

ER -