ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5

Stefano Fratoni; Pasquale Niscola; Xiangfeng Frank Zhao; Luigi Maria Larocca; Anna Capalbo; Maria Fabbretti; Laura Bernardini; Elisabetta Abruzzese

doi:10.1016/j.prp.2019.152724

ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5

Stefano Fratoni, Pasquale Niscola, Xiangfeng Frank Zhao, Luigi Maria Larocca, Anna Capalbo, Maria Fabbretti, Laura Bernardini, Elisabetta Abruzzese

Research output: Contribution to journal › Article

Abstract

Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.

Original language	English
Article number	152724
Journal	Pathology Research and Practice
Volume	216
Issue number	2
DOIs	https://doi.org/10.1016/j.prp.2019.152724
Publication status	Published - Feb 2020

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Keywords

ALK-negative anaplastic large cell lymphoma
PAX5
“Hodgkin-like” features

ASJC Scopus subject areas

Pathology and Forensic Medicine
Cell Biology

Cite this

Fratoni, S., Niscola, P., Zhao, X. F., Larocca, L. M., Capalbo, A., Fabbretti, M., Bernardini, L., & Abruzzese, E. (2020). ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5. Pathology Research and Practice, 216(2), [152724]. https://doi.org/10.1016/j.prp.2019.152724

ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5. / Fratoni, Stefano; Niscola, Pasquale; Zhao, Xiangfeng Frank; Larocca, Luigi Maria; Capalbo, Anna; Fabbretti, Maria; Bernardini, Laura; Abruzzese, Elisabetta.

In: Pathology Research and Practice, Vol. 216, No. 2, 152724, 02.2020.

Research output: Contribution to journal › Article

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abstract = "Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.",

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AU - Niscola, Pasquale

AU - Zhao, Xiangfeng Frank

AU - Larocca, Luigi Maria

AU - Capalbo, Anna

AU - Fabbretti, Maria

AU - Bernardini, Laura

AU - Abruzzese, Elisabetta

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N2 - Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.

AB - Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.

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CASA SOLLIEVO SOFFERENZA - MECCANISMI PATOGENETICI E TERAPIA DELLE MALATTIE RARE

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ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5

Abstract

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Keywords

ASJC Scopus subject areas

Cite this

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CASA SOLLIEVO SOFFERENZA - MECCANISMI PATOGENETICI E TERAPIA DELLE MALATTIE RARE