Abstract
Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.
| Original language | English |
|---|---|
| Article number | 152724 |
| Journal | Pathology Research and Practice |
| Volume | 216 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2020 |
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Keywords
- ALK-negative anaplastic large cell lymphoma
- PAX5
- “Hodgkin-like” features
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Cell Biology
Cite this
ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5. / Fratoni, Stefano; Niscola, Pasquale; Zhao, Xiangfeng Frank; Larocca, Luigi Maria; Capalbo, Anna; Fabbretti, Maria; Bernardini, Laura; Abruzzese, Elisabetta.
In: Pathology Research and Practice, Vol. 216, No. 2, 152724, 02.2020.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5
AU - Fratoni, Stefano
AU - Niscola, Pasquale
AU - Zhao, Xiangfeng Frank
AU - Larocca, Luigi Maria
AU - Capalbo, Anna
AU - Fabbretti, Maria
AU - Bernardini, Laura
AU - Abruzzese, Elisabetta
PY - 2020/2
Y1 - 2020/2
N2 - Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.
AB - Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.
KW - ALK-negative anaplastic large cell lymphoma
KW - PAX5
KW - “Hodgkin-like” features
UR - http://www.scopus.com/inward/record.url?scp=85078552392&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078552392&partnerID=8YFLogxK
U2 - 10.1016/j.prp.2019.152724
DO - 10.1016/j.prp.2019.152724
M3 - Article
C2 - 31784094
AN - SCOPUS:85078552392
VL - 216
JO - Pathology Research and Practice
JF - Pathology Research and Practice
SN - 0344-0338
IS - 2
M1 - 152724
ER -