Alkaloids in the nature

pharmacological applications in clinical practice of berberine and mate tea.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

alkaloids are a group of naturally occurring chemical compounds that contain mostly basic nitrogen atoms. In particular berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids with anti-lipogenic and hypoglycemic effects. On the other hand, mate plant has reported to have high antioxidant potential, including an inhibitory ability against plasma and LDL oxidation. Most of the studies reported in literature about alkaloids are pre-clinical trials, and we have already discussed them in a previous review we conducted. This time we want to focus our attention on clinical studies about berberine, and mate plant, so the aim of this review is to evaluate berberine and mate plant efficacy and safety in humans. Berberine is a potent oral hypoglycemic agent with a good effect on lipid metabolism. It is safe and the cost of treatment is very low. Also mate plant seems to have antioxidant and hypolipidemic actions, even if further studies are necessary.

Original languageEnglish
Pages (from-to)200-206
Number of pages7
JournalCurrent Topics in Medicinal Chemistry
Volume14
Issue number2
Publication statusPublished - 2014

Fingerprint

Berberine
Tea
Alkaloids
Pharmacology
Hypoglycemic Agents
Antioxidants
Ammonium Compounds
Lipid Metabolism
Health Care Costs
Nitrogen
Salts
Clinical Trials
Safety

ASJC Scopus subject areas

  • Drug Discovery

Cite this

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abstract = "alkaloids are a group of naturally occurring chemical compounds that contain mostly basic nitrogen atoms. In particular berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids with anti-lipogenic and hypoglycemic effects. On the other hand, mate plant has reported to have high antioxidant potential, including an inhibitory ability against plasma and LDL oxidation. Most of the studies reported in literature about alkaloids are pre-clinical trials, and we have already discussed them in a previous review we conducted. This time we want to focus our attention on clinical studies about berberine, and mate plant, so the aim of this review is to evaluate berberine and mate plant efficacy and safety in humans. Berberine is a potent oral hypoglycemic agent with a good effect on lipid metabolism. It is safe and the cost of treatment is very low. Also mate plant seems to have antioxidant and hypolipidemic actions, even if further studies are necessary.",
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