Alkylation of γ-(4-nitrobenzyl)pyridine by four N-diazoacetyl derivatives of amino acids. Lack of fine correlation with the unscheduled DNA synthesis induced in mouse cells "In vitro"

S. Parodi, M. Picca, C. Bolognesi, M. Cavanna, P. Carlo, R. Finollo, G. Brambilla

Research output: Contribution to journalArticlepeer-review

Abstract

Four N-diazoacetyl derivatives of amino acids, N-diazoacetylglycine amide (DGA), N-diazoacetylglycine methylamide (DGMA), N-diazoacetylglycine hydrazide (DGI), and N-diazoacetyl-D,L-alanine ethyl ester (DAE), two of them, DGA and DGI, known to be carcinogens and mutagens, were quantitatively assayed for both alkylation of the acceptor γ-(4-nitrobenzyl)pyridine and autoradiographic DNA repair induced in mouse cell cultures. All four compounds were positive for the above mentioned effects but there was no fine quantitative correlation between them.

Original languageEnglish
Pages (from-to)621-631
Number of pages11
JournalPharmacological Research Communications
Volume9
Issue number7
DOIs
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Pharmacology

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