ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy

Giuseppe Cimino, Francesco Lo Coco, Andrea Biondi, Loredana Elia, Anna Luciano, Carlo M. Croce, Giuseppe Masera, Franco Mandelli, Eli Canaani

Research output: Contribution to journalArticle

Abstract

Early infancy ( <1 year of age), massive tumor cell burden, and extremely poor prognosis are characteristic features of a particular subset of childhood acute leukemias (AL). In these cases, chromosome aberrations at the 11q23 band are the most frequently reported cytogenetic abnormalities. We have recently cloned a genetic locus named ALL-1, in which DNA breakpoints are clustered in leukemic patients with 11q23 aberrations. Analysis of the ALL-1 genomic configuration in DNA from 15 infants with AL showed specific ALL-1 rearrangements in 12 cases (80%), including 5 with normal karyotypes. These findings indicate that a consistent genetic defect underlies this particular leukemic subset.

Original languageEnglish
Pages (from-to)544-546
Number of pages3
JournalBlood
Volume82
Issue number2
Publication statusPublished - Jul 15 1993

ASJC Scopus subject areas

  • Hematology

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    Cimino, G., Lo Coco, F., Biondi, A., Elia, L., Luciano, A., Croce, C. M., Masera, G., Mandelli, F., & Canaani, E. (1993). ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy. Blood, 82(2), 544-546.