All-trans-retinoic Acid Modulates the plasticity and inhibits the motility of breast cancer cells role of notch1 and transforming growth factor (TGF β)

Adriana Zanetti, Roberta Affatato, Floriana Centritto, Maddalena Fratelli, Mami Kurosaki, Maria Monica Barzago, Marco Bolis, Mineko Terao, Enrico Garattini, Gabriela Paroni

Research output: Contribution to journal › Article

Abstract

Background: All-trans-retinoic acid is a promising therapeutic agent in breast cancer. Results: All-trans-retinoic acid modulates mammary tumor cell epithelial-to-mesenchymal-transition via the TGF β and NOTCH pathways. Conclusion: The present study unveils a new aspect of all-trans-retinoic acid activity (i.e. regulation of phenotypic cell plasticity). Significance: Our results indicate that all-trans-retinoic acid is endowed with anti-metastatic properties that could be exploited at the therapeutic level.

Original languageEnglish
Pages (from-to)17690-17709
Number of pages20
JournalJournal of Biological Chemistry
Volume290
Issue number29
DOIs
Publication statusPublished - Jul 17 2015

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Transforming Growth Factors
Tretinoin
Plasticity
Cells
Breast Neoplasms
Epithelial-Mesenchymal Transition
Tumors
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

All-trans-retinoic Acid Modulates the plasticity and inhibits the motility of breast cancer cells role of notch1 and transforming growth factor (TGF β). / Zanetti, Adriana; Affatato, Roberta; Centritto, Floriana; Fratelli, Maddalena; Kurosaki, Mami; Barzago, Maria Monica; Bolis, Marco; Terao, Mineko; Garattini, Enrico; Paroni, Gabriela.

In: Journal of Biological Chemistry, Vol. 290, No. 29, 17.07.2015, p. 17690-17709.

Research output: Contribution to journal › Article

Zanetti, A, Affatato, R, Centritto, F, Fratelli, M, Kurosaki, M, Barzago, MM, Bolis, M, Terao, M, Garattini, E & Paroni, G 2015, 'All-trans-retinoic Acid Modulates the plasticity and inhibits the motility of breast cancer cells role of notch1 and transforming growth factor (TGF β)', Journal of Biological Chemistry, vol. 290, no. 29, pp. 17690-17709. https://doi.org/10.1074/jbc.M115.638510
Zanetti A, Affatato R, Centritto F, Fratelli M, Kurosaki M, Barzago MM et al. All-trans-retinoic Acid Modulates the plasticity and inhibits the motility of breast cancer cells role of notch1 and transforming growth factor (TGF β). Journal of Biological Chemistry. 2015 Jul 17;290(29):17690-17709. https://doi.org/10.1074/jbc.M115.638510
Zanetti, Adriana ; Affatato, Roberta ; Centritto, Floriana ; Fratelli, Maddalena ; Kurosaki, Mami ; Barzago, Maria Monica ; Bolis, Marco ; Terao, Mineko ; Garattini, Enrico ; Paroni, Gabriela. / All-trans-retinoic Acid Modulates the plasticity and inhibits the motility of breast cancer cells role of notch1 and transforming growth factor (TGF β). In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 29. pp. 17690-17709.
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AU - Kurosaki, Mami

AU - Barzago, Maria Monica

AU - Bolis, Marco

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