All-trans-retinoic Acid Modulates the plasticity and inhibits the motility of breast cancer cells role of notch1 and transforming growth factor (TGF β)

Adriana Zanetti, Roberta Affatato, Floriana Centritto, Maddalena Fratelli, Mami Kurosaki, Maria Monica Barzago, Marco Bolis, Mineko Terao, Enrico Garattini, Gabriela Paroni

Research output: Contribution to journalArticle

Abstract

Background: All-trans-retinoic acid is a promising therapeutic agent in breast cancer. Results: All-trans-retinoic acid modulates mammary tumor cell epithelial-to-mesenchymal-transition via the TGF β and NOTCH pathways. Conclusion: The present study unveils a new aspect of all-trans-retinoic acid activity (i.e. regulation of phenotypic cell plasticity). Significance: Our results indicate that all-trans-retinoic acid is endowed with anti-metastatic properties that could be exploited at the therapeutic level.

Original languageEnglish
Pages (from-to)17690-17709
Number of pages20
JournalJournal of Biological Chemistry
Volume290
Issue number29
DOIs
Publication statusPublished - Jul 17 2015

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Transforming Growth Factors
Tretinoin
Plasticity
Cells
Breast Neoplasms
Epithelial-Mesenchymal Transition
Tumors
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

All-trans-retinoic Acid Modulates the plasticity and inhibits the motility of breast cancer cells role of notch1 and transforming growth factor (TGF β). / Zanetti, Adriana; Affatato, Roberta; Centritto, Floriana; Fratelli, Maddalena; Kurosaki, Mami; Barzago, Maria Monica; Bolis, Marco; Terao, Mineko; Garattini, Enrico; Paroni, Gabriela.

In: Journal of Biological Chemistry, Vol. 290, No. 29, 17.07.2015, p. 17690-17709.

Research output: Contribution to journalArticle

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AU - Affatato, Roberta

AU - Centritto, Floriana

AU - Fratelli, Maddalena

AU - Kurosaki, Mami

AU - Barzago, Maria Monica

AU - Bolis, Marco

AU - Terao, Mineko

AU - Garattini, Enrico

AU - Paroni, Gabriela

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