All-trans-retinoic Acid Modulates the plasticity and inhibits the motility of breast cancer cells role of notch1 and transforming growth factor (TGF β)

Adriana Zanetti, Roberta Affatato, Floriana Centritto, Maddalena Fratelli, Mami Kurosaki, Maria Monica Barzago, Marco Bolis, Mineko Terao, Enrico Garattini, Gabriela Paroni

Research output: Contribution to journalArticlepeer-review

Abstract

Background: All-trans-retinoic acid is a promising therapeutic agent in breast cancer. Results: All-trans-retinoic acid modulates mammary tumor cell epithelial-to-mesenchymal-transition via the TGF β and NOTCH pathways. Conclusion: The present study unveils a new aspect of all-trans-retinoic acid activity (i.e. regulation of phenotypic cell plasticity). Significance: Our results indicate that all-trans-retinoic acid is endowed with anti-metastatic properties that could be exploited at the therapeutic level.

Original languageEnglish
Pages (from-to)17690-17709
Number of pages20
JournalJournal of Biological Chemistry
Volume290
Issue number29
DOIs
Publication statusPublished - Jul 17 2015

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'All-trans-retinoic Acid Modulates the plasticity and inhibits the motility of breast cancer cells role of notch1 and transforming growth factor (TGF β)'. Together they form a unique fingerprint.

Cite this