TY - JOUR
T1 - All-trans-retinoic Acid Modulates the plasticity and inhibits the motility of breast cancer cells role of notch1 and transforming growth factor (TGF β)
AU - Zanetti, Adriana
AU - Affatato, Roberta
AU - Centritto, Floriana
AU - Fratelli, Maddalena
AU - Kurosaki, Mami
AU - Barzago, Maria Monica
AU - Bolis, Marco
AU - Terao, Mineko
AU - Garattini, Enrico
AU - Paroni, Gabriela
PY - 2015/7/17
Y1 - 2015/7/17
N2 - Background: All-trans-retinoic acid is a promising therapeutic agent in breast cancer. Results: All-trans-retinoic acid modulates mammary tumor cell epithelial-to-mesenchymal-transition via the TGF β and NOTCH pathways. Conclusion: The present study unveils a new aspect of all-trans-retinoic acid activity (i.e. regulation of phenotypic cell plasticity). Significance: Our results indicate that all-trans-retinoic acid is endowed with anti-metastatic properties that could be exploited at the therapeutic level.
AB - Background: All-trans-retinoic acid is a promising therapeutic agent in breast cancer. Results: All-trans-retinoic acid modulates mammary tumor cell epithelial-to-mesenchymal-transition via the TGF β and NOTCH pathways. Conclusion: The present study unveils a new aspect of all-trans-retinoic acid activity (i.e. regulation of phenotypic cell plasticity). Significance: Our results indicate that all-trans-retinoic acid is endowed with anti-metastatic properties that could be exploited at the therapeutic level.
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U2 - 10.1074/jbc.M115.638510
DO - 10.1074/jbc.M115.638510
M3 - Article
C2 - 26018078
AN - SCOPUS:84937389325
VL - 290
SP - 17690
EP - 17709
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 29
ER -