Allele ε4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy

Paolo Bosco, Rosa Maria Guéant-Rodríguez, Guido Anello, Rosario S. Spada, Antonino Romano, Filippo Caraci, Raffaele Ferri, Jean Louis Guéant

Research output: Contribution to journalArticlepeer-review

Abstract

The genotype of apolipoprotein E was examined in 173 sporadic Alzheimer's disease (AD) patients, 132 with late onset (LOAD) and 41 with early onset (EOAD), and in 174 healthy matched controls from Sicily. Despite a low frequency of the ε4 allele (6.3%, 95% CI: 4.2-9.4) in controls, ε4 allele was a stronger predictor of AD risk (odds ratio: 5.8, 95% CI: 3.5-9.4; p <0.0001) than in most of the studies performed in other regions of Italy, and it has no influence on age at onset. ε4/ε4 and ε4/ε3 genotypes were similar predictors of AD risk. Conversely, a decreased risk was found in ε3 allele carriers (odds ratio: 0.3, 95% CI: 0.2-0.4; p <0.0001), which remained significant when considering EOAD cases only (odds ratio: 0.2, 95% CI: 0.1-0.4, p <0.0001). In conclusion, differences in association strength of ε4 allele with AD between Sicily and other regions of Italy suggest an influence of complex gene-gene and gene-environment interactions.

Original languageEnglish
Pages (from-to)168-172
Number of pages5
JournalNeuroscience Letters
Volume388
Issue number3
DOIs
Publication statusPublished - Nov 18 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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