TY - JOUR
T1 - Allele ε4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy
AU - Bosco, Paolo
AU - Guéant-Rodríguez, Rosa Maria
AU - Anello, Guido
AU - Spada, Rosario S.
AU - Romano, Antonino
AU - Caraci, Filippo
AU - Ferri, Raffaele
AU - Guéant, Jean Louis
PY - 2005/11/18
Y1 - 2005/11/18
N2 - The genotype of apolipoprotein E was examined in 173 sporadic Alzheimer's disease (AD) patients, 132 with late onset (LOAD) and 41 with early onset (EOAD), and in 174 healthy matched controls from Sicily. Despite a low frequency of the ε4 allele (6.3%, 95% CI: 4.2-9.4) in controls, ε4 allele was a stronger predictor of AD risk (odds ratio: 5.8, 95% CI: 3.5-9.4; p <0.0001) than in most of the studies performed in other regions of Italy, and it has no influence on age at onset. ε4/ε4 and ε4/ε3 genotypes were similar predictors of AD risk. Conversely, a decreased risk was found in ε3 allele carriers (odds ratio: 0.3, 95% CI: 0.2-0.4; p <0.0001), which remained significant when considering EOAD cases only (odds ratio: 0.2, 95% CI: 0.1-0.4, p <0.0001). In conclusion, differences in association strength of ε4 allele with AD between Sicily and other regions of Italy suggest an influence of complex gene-gene and gene-environment interactions.
AB - The genotype of apolipoprotein E was examined in 173 sporadic Alzheimer's disease (AD) patients, 132 with late onset (LOAD) and 41 with early onset (EOAD), and in 174 healthy matched controls from Sicily. Despite a low frequency of the ε4 allele (6.3%, 95% CI: 4.2-9.4) in controls, ε4 allele was a stronger predictor of AD risk (odds ratio: 5.8, 95% CI: 3.5-9.4; p <0.0001) than in most of the studies performed in other regions of Italy, and it has no influence on age at onset. ε4/ε4 and ε4/ε3 genotypes were similar predictors of AD risk. Conversely, a decreased risk was found in ε3 allele carriers (odds ratio: 0.3, 95% CI: 0.2-0.4; p <0.0001), which remained significant when considering EOAD cases only (odds ratio: 0.2, 95% CI: 0.1-0.4, p <0.0001). In conclusion, differences in association strength of ε4 allele with AD between Sicily and other regions of Italy suggest an influence of complex gene-gene and gene-environment interactions.
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U2 - 10.1016/j.neulet.2005.06.056
DO - 10.1016/j.neulet.2005.06.056
M3 - Article
C2 - 16040191
AN - SCOPUS:23944436653
VL - 388
SP - 168
EP - 172
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -