Allele ε4 of apolipoprotein E gene is less frequent in Down syndrome patient of the Sicilian population and has no influence on the grade of mental retardation

Guido Anello, Jean Louis Guéant, Corrado Romano, Concetta Barone, Rosa Pettinato, Thierry Pillot, Rosa Maria Rodriguez, Antonino Romano, Paolo Bosco

Research output: Contribution to journalArticle

Abstract

We evaluated the allele (and genotype frequencies in 60 Down syndrome (DS), 25 mothers and 57 controls from Sicily and its relation with mental retardation. DS patients and sex ratio (M:F) was 22.1 ± 10.5 and 1.14, respectively. Allele ε4 and ε3 frequencies were respectively lower (P = 0.015) and higher (P = 0.005) in DS patients compared to controls. Genotype ε3/ε4 and ε3/ε3 were less (P = 0.03) and more frequent (P = 0.001) in DS patients, with respective odd ratios of 0.31 (CI at 95%: 0.18-0.49) and of 4.4 (CI at 95%: 3.4-5.7). No difference of allele (distribution was found in function of the grades of mental retardation according to DMS-IV. Our results show that the implication of Apo-E4 in the pathogenesis of Alzheimer disease cannot be extrapolated in that of dementia of DS.

Original languageEnglish
Pages (from-to)129-131
Number of pages3
JournalNeuroscience Letters
Volume306
Issue number1-2
DOIs
Publication statusPublished - Jun 22 2001

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Down syndrome
  • Mental retardation
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Neuroscience(all)

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