Allele frequencies of +874T → A single nucleotide polymorphism at the first intron of interferon-γ gene in a group of Italian centenarians

Domenico Lio, Letizia Scola, Antonio Crivello, Massimiliano Bonafè, Claudio Franceschi, Fabiola Olivieri, Giuseppina Colonna-Romano, Giuseppina Candore, Calogero Caruso

Research output: Contribution to journalArticlepeer-review

Abstract

Ageing is characterized by a pro-inflammatory status which could contribute to the onset of major age-related diseases such as cardiovascular diseases, neurodegeneration, osteoarthritis and osteoporosis, and diabetes. Thus, it can be hypothesized that genetic variations in pro- or anti-inflammatory cytokines might influence successful ageing and longevity. We have studied the distribution of +874T → A interferon-γ (IFN-γ) polymorphisms in a large number of Italian centenarians to evaluate if the two alleles might be differently represented in people selected for longevity. DNA samples were obtained from 174 Italian centenarians (>99 years old, 142 women and 32 men) and from 248

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalExperimental Gerontology
Volume37
Issue number2-3
DOIs
Publication statusPublished - Jan 3 2002

Keywords

  • Centenarians
  • Immunogenetics
  • Inflammation
  • Interferon-γ
  • Longevity

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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