Allelic imbalance on chromosome 3p in oral dysplastic lesions: An early event in oral carcinogenesis

Luca Roz, Chu Lee Wu, Stephen Porter, Crispian Scully, Paul Speight, Andrew Read, Philip Sloan, Nalin Thakker

Research output: Contribution to journalArticlepeer-review

Abstract

We have demonstrated previously a loss of constitutional heterozygosity on the short arm of chromosome 3 in ~50% of oral squamous cell carcinomas. In the present study, we have investigated 30 oral dysplastic lesions (DLs), presenting clinically as either erythroplakias or leukoplakias with histopathological features of either severe epithelial dysplasia or carcinoma in situ, for LOH on chromosome 3p using 15 microsatellite markers. Thirteen of the 30 DLs (~43%) showed allelic imbalance at one or more loci. The pattern of loss in these lesions defined three noncontiguous regions of interstitial deletions that overlap with those defined for oral squamous cell carcinomas. These data indicate that the alteration of tumor suppressor genes on chromosome 3p is probably an early event in oral carcinogenesis. Additionally, 7 of the 30 DLs showed microsatellite instability. However, the frequency of loci showing microsatellite instability per lesion was low.

Original languageEnglish
Pages (from-to)1228-1231
Number of pages4
JournalCancer Research
Volume56
Issue number6
Publication statusPublished - Mar 15 1996

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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