TY - JOUR
T1 - Allelic imbalance on chromosome 3p in oral dysplastic lesions
T2 - An early event in oral carcinogenesis
AU - Roz, Luca
AU - Wu, Chu Lee
AU - Porter, Stephen
AU - Scully, Crispian
AU - Speight, Paul
AU - Read, Andrew
AU - Sloan, Philip
AU - Thakker, Nalin
PY - 1996/3/15
Y1 - 1996/3/15
N2 - We have demonstrated previously a loss of constitutional heterozygosity on the short arm of chromosome 3 in ~50% of oral squamous cell carcinomas. In the present study, we have investigated 30 oral dysplastic lesions (DLs), presenting clinically as either erythroplakias or leukoplakias with histopathological features of either severe epithelial dysplasia or carcinoma in situ, for LOH on chromosome 3p using 15 microsatellite markers. Thirteen of the 30 DLs (~43%) showed allelic imbalance at one or more loci. The pattern of loss in these lesions defined three noncontiguous regions of interstitial deletions that overlap with those defined for oral squamous cell carcinomas. These data indicate that the alteration of tumor suppressor genes on chromosome 3p is probably an early event in oral carcinogenesis. Additionally, 7 of the 30 DLs showed microsatellite instability. However, the frequency of loci showing microsatellite instability per lesion was low.
AB - We have demonstrated previously a loss of constitutional heterozygosity on the short arm of chromosome 3 in ~50% of oral squamous cell carcinomas. In the present study, we have investigated 30 oral dysplastic lesions (DLs), presenting clinically as either erythroplakias or leukoplakias with histopathological features of either severe epithelial dysplasia or carcinoma in situ, for LOH on chromosome 3p using 15 microsatellite markers. Thirteen of the 30 DLs (~43%) showed allelic imbalance at one or more loci. The pattern of loss in these lesions defined three noncontiguous regions of interstitial deletions that overlap with those defined for oral squamous cell carcinomas. These data indicate that the alteration of tumor suppressor genes on chromosome 3p is probably an early event in oral carcinogenesis. Additionally, 7 of the 30 DLs showed microsatellite instability. However, the frequency of loci showing microsatellite instability per lesion was low.
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M3 - Article
C2 - 8640803
AN - SCOPUS:13344262679
VL - 56
SP - 1228
EP - 1231
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 6
ER -