Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11

P. Radice, D. Perotti, V. De Benedetti, P. Mondini, M. T. Radice, S. Pilotti, R. Luksch, F. F. Bellani, M. A. Pierotti

Research output: Contribution to journalArticle

Abstract

An analysis of loss of heterozygosity for markers on both the short and the long arm of chromosome 11 was performed in 24 sporadic Wilms tumors. Six cases (25%) showed allelic losses involving the entire chromosome. In one case (4%) the loss was restricted solely to the WT1 gene on band p13. Two cases (8%) displayed allelic losses for WT1 and for markers on band p15.5, where the putative tumor suppressor gene WT2 has been mapped, but retained heterozygosity for markers on the long arm. In three tumors (13%) the loss of heterozygosity involved markers mapped to chromosomal regions p15.5 and q23.3-qter, but did not affect WT1 and markers on q12-q13. Altogether, the proportion of cases showing allelic losses at the distal region of 11q (37%) was comparable to that of cases with LOH affecting the WT1 (37%) or the WT2 (46%) loci, thus suggesting the existence of a third chromosome 11 tumor suppressor gene involved in the pathogenesis of Wilms tumors.

Original languageEnglish
Pages (from-to)497-501
Number of pages5
JournalGenomics
Volume27
Issue number3
DOIs
Publication statusPublished - 1995

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Chromosomes, Human, Pair 11
Wilms Tumor
Loss of Heterozygosity
Tumor Suppressor Genes
Chromosomes
Genes
Neoplasms

ASJC Scopus subject areas

  • Genetics

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Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11. / Radice, P.; Perotti, D.; De Benedetti, V.; Mondini, P.; Radice, M. T.; Pilotti, S.; Luksch, R.; Bellani, F. F.; Pierotti, M. A.

In: Genomics, Vol. 27, No. 3, 1995, p. 497-501.

Research output: Contribution to journalArticle

Radice, P, Perotti, D, De Benedetti, V, Mondini, P, Radice, MT, Pilotti, S, Luksch, R, Bellani, FF & Pierotti, MA 1995, 'Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11', Genomics, vol. 27, no. 3, pp. 497-501. https://doi.org/10.1006/geno.1995.1082
Radice, P. ; Perotti, D. ; De Benedetti, V. ; Mondini, P. ; Radice, M. T. ; Pilotti, S. ; Luksch, R. ; Bellani, F. F. ; Pierotti, M. A. / Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11. In: Genomics. 1995 ; Vol. 27, No. 3. pp. 497-501.
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abstract = "An analysis of loss of heterozygosity for markers on both the short and the long arm of chromosome 11 was performed in 24 sporadic Wilms tumors. Six cases (25{\%}) showed allelic losses involving the entire chromosome. In one case (4{\%}) the loss was restricted solely to the WT1 gene on band p13. Two cases (8{\%}) displayed allelic losses for WT1 and for markers on band p15.5, where the putative tumor suppressor gene WT2 has been mapped, but retained heterozygosity for markers on the long arm. In three tumors (13{\%}) the loss of heterozygosity involved markers mapped to chromosomal regions p15.5 and q23.3-qter, but did not affect WT1 and markers on q12-q13. Altogether, the proportion of cases showing allelic losses at the distal region of 11q (37{\%}) was comparable to that of cases with LOH affecting the WT1 (37{\%}) or the WT2 (46{\%}) loci, thus suggesting the existence of a third chromosome 11 tumor suppressor gene involved in the pathogenesis of Wilms tumors.",
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AU - Perotti, D.

AU - De Benedetti, V.

AU - Mondini, P.

AU - Radice, M. T.

AU - Pilotti, S.

AU - Luksch, R.

AU - Bellani, F. F.

AU - Pierotti, M. A.

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