Allergen-specific immunotherapy: An update on immunological mechanisms of action

Giorgio Ciprandi, G. L. Marseglia, M. A. Tosca

Research output: Contribution to journalArticlepeer-review

Abstract

Specific immunotherapy (SIT) is the only treatment able to modify the natural history of the allergic subjects. Several aspects of the immunopathological response modified by SIT have been investigated; the first parameter historically studied was the production of allergen-specific antibodies. An increase of allergen-specific IgG4 and a decrease of IgE appear after SIT. A shift from Th2-polarized immune response toward Th1-oriented pattern has been reported after SIT. More recently, a crucial role for a subpopulation of T cells has been evidenced: T regulatory cells (Treg). Allergic patients have a defect of Tregs. SIT is able of inducing a specific Treg response. Sublingual imm unotherapy is an alternative route of administration for SIT. Recent evidence shows that SLIT is also able of inducing a Treg response as detected by IL-10 production.

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalMonaldi Archives for Chest Disease - Cardiac Series
Volume65
Issue number1
Publication statusPublished - Mar 2006

Keywords

  • Allergen-specific immunotherapy
  • Atopy
  • IgE
  • IgG

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine

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