Allergen-specific immunotherapy: An update on immunological mechanisms of action

Giorgio Ciprandi, G. L. Marseglia, M. A. Tosca

Research output: Contribution to journalArticlepeer-review


Specific immunotherapy (SIT) is the only treatment able to modify the natural history of the allergic subjects. Several aspects of the immunopathological response modified by SIT have been investigated; the first parameter historically studied was the production of allergen-specific antibodies. An increase of allergen-specific IgG4 and a decrease of IgE appear after SIT. A shift from Th2-polarized immune response toward Th1-oriented pattern has been reported after SIT. More recently, a crucial role for a subpopulation of T cells has been evidenced: T regulatory cells (Treg). Allergic patients have a defect of Tregs. SIT is able of inducing a specific Treg response. Sublingual imm unotherapy is an alternative route of administration for SIT. Recent evidence shows that SLIT is also able of inducing a Treg response as detected by IL-10 production.

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalMonaldi Archives for Chest Disease - Cardiac Series
Issue number1
Publication statusPublished - Mar 2006


  • Allergen-specific immunotherapy
  • Atopy
  • IgE
  • IgG

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine


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