Allergen-Specific Immunotherapy for Respiratory Allergy in Children: Unmet Needs and Future Goals

Pasquale Comberiati, Gian Luigi Marseglia, Salvatore Barberi, Giovanni Passalacqua, Diego G. Peroni

Research output: Contribution to journalArticlepeer-review

Abstract

Allergen-specific immunotherapy for the treatment of respiratory allergy is currently supported, at least for selected products, by evidence of efficacy and effectiveness in the pediatric age. However, unmet needs remain in terms of administration regimens, duration of treatment, biomarkers, and preventive effects. These knowledge gaps need to be urgently addressed to provide pediatricians and pediatric allergists with more definite recommendations for the use of this treatment in children. This article critically appraises the most relevant debated issues on allergen-specific immunotherapy in children, focusing on allergen standardization procedures, heterogeneity of clinical studies, and regulatory and pharmacoeconomic aspects.

Original languageEnglish
Pages (from-to)946-950
Number of pages5
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume5
Issue number4
DOIs
Publication statusPublished - Jul 1 2017

Keywords

  • Allergen-specific immunotherapy
  • Allergic rhinitis
  • Allergy
  • Asthma
  • Children
  • Subcutaneous immunotherapy
  • Sublingual immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy

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