Allergic bronchial airway inflammation in nerve growth factor (NGF)-deprived rats: Evidence suggesting a neuroimmunomodulatory role of NGF

Barbara Stampachiacchiere; Luigi Aloe; Alessandra Micera; Sergio Bonini

doi:10.1080/01902140600916952

Allergic bronchial airway inflammation in nerve growth factor (NGF)-deprived rats: Evidence suggesting a neuroimmunomodulatory role of NGF

Barbara Stampachiacchiere, Luigi Aloe, Alessandra Micera, Sergio Bonini

Fondazione G.B. Bietti

Research output: Contribution to journal › Article › peer-review

Abstract

In the present study, ovalbumin-sensitized/challenged rats were characterized by an nerve growth factor (NGF) increase in both serum and bronchial alveolar lavage fluid (BALF), but not in the lung. Exogenous administration of NGF or NGF-neutralizing antibodies did not modify immunoglobulin (IgE) and eosinophil parameters. In control rats, NGF administration did not induce increase of IgE or eosinophils in both BALF and lung. The present findings suggest that at least NGF does not act as a proper proinflammatory factor but most probably as a neuroimmune modulator molecule of the allergic state.

Original language	English
Pages (from-to)	305-320
Number of pages	16
Journal	Experimental Lung Research
Volume	32
Issue number	7
DOIs	https://doi.org/10.1080/01902140600916952
Publication status	Published - Aug 1 2006

Keywords

Allergy
Eosinophils
Inflammation
Mast cells
NGF

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1080/01902140600916952

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