TY - JOUR
T1 - Allergic bronchial airway inflammation in nerve growth factor (NGF)-deprived rats
T2 - Evidence suggesting a neuroimmunomodulatory role of NGF
AU - Stampachiacchiere, Barbara
AU - Aloe, Luigi
AU - Micera, Alessandra
AU - Bonini, Sergio
PY - 2006/8/1
Y1 - 2006/8/1
N2 - In the present study, ovalbumin-sensitized/challenged rats were characterized by an nerve growth factor (NGF) increase in both serum and bronchial alveolar lavage fluid (BALF), but not in the lung. Exogenous administration of NGF or NGF-neutralizing antibodies did not modify immunoglobulin (IgE) and eosinophil parameters. In control rats, NGF administration did not induce increase of IgE or eosinophils in both BALF and lung. The present findings suggest that at least NGF does not act as a proper proinflammatory factor but most probably as a neuroimmune modulator molecule of the allergic state.
AB - In the present study, ovalbumin-sensitized/challenged rats were characterized by an nerve growth factor (NGF) increase in both serum and bronchial alveolar lavage fluid (BALF), but not in the lung. Exogenous administration of NGF or NGF-neutralizing antibodies did not modify immunoglobulin (IgE) and eosinophil parameters. In control rats, NGF administration did not induce increase of IgE or eosinophils in both BALF and lung. The present findings suggest that at least NGF does not act as a proper proinflammatory factor but most probably as a neuroimmune modulator molecule of the allergic state.
KW - Allergy
KW - Eosinophils
KW - Inflammation
KW - Mast cells
KW - NGF
UR - http://www.scopus.com/inward/record.url?scp=33750317547&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750317547&partnerID=8YFLogxK
U2 - 10.1080/01902140600916952
DO - 10.1080/01902140600916952
M3 - Article
C2 - 17060174
AN - SCOPUS:33750317547
VL - 32
SP - 305
EP - 320
JO - Experimental Lung Research
JF - Experimental Lung Research
SN - 0190-2148
IS - 7
ER -