Allergic bronchial airway inflammation in nerve growth factor (NGF)-deprived rats: Evidence suggesting a neuroimmunomodulatory role of NGF

Barbara Stampachiacchiere, Luigi Aloe, Alessandra Micera, Sergio Bonini

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study, ovalbumin-sensitized/challenged rats were characterized by an nerve growth factor (NGF) increase in both serum and bronchial alveolar lavage fluid (BALF), but not in the lung. Exogenous administration of NGF or NGF-neutralizing antibodies did not modify immunoglobulin (IgE) and eosinophil parameters. In control rats, NGF administration did not induce increase of IgE or eosinophils in both BALF and lung. The present findings suggest that at least NGF does not act as a proper proinflammatory factor but most probably as a neuroimmune modulator molecule of the allergic state.

Original languageEnglish
Pages (from-to)305-320
Number of pages16
JournalExperimental Lung Research
Volume32
Issue number7
DOIs
Publication statusPublished - Aug 1 2006

Keywords

  • Allergy
  • Eosinophils
  • Inflammation
  • Mast cells
  • NGF

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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