Allergic fungal rhinosinusitis due to Curvularia lunata

Caterin Cavanna, Elen Seminari, Alessandr Pusateri, Francesc Mangione, Fabiol Lallitto, Maria Carmela Esposto, Fabi Pagella

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We report a case of Curvularia lunata infection in an immunocompetent male with an initial diagnosis of suspected left side allergic fungal rhinosinusitis (AFRS), treated surgically. He had a relapse of nasal polyposis and underwent a surgical revision under local anaesthesia with endoscopic nasal polypectomy. The histological examination of the surgical specimen showed an inflammatory polyp of the paranasal sinuses, with eosinophil and lymphocyte infiltration, but without evidence of fungi. However, Curvularia spp fungus grew in cultures of nasal sinus drainage and bioptical specimens. The fungus was identified by DNA sequencing as C. lunata. The patient was then treated with itraconazole (200 mg BID for 4 weeks), mometasone furoate nasal spray (100 mcg BID for 6 months) and normal saline nasal irrigations. At the last follow-up endoscopic evaluation after 19 month from treatment, the patient was symptomless and free from disease. No polyp recurrence nor seromucous discharges were noticed. This first case of C. lunata-associated AFRS reported in Italy, highlights the difficulty of this diagnosis and the usefulness of molecular identification of the fungal species involved.

Original languageEnglish
Pages (from-to)241-245
Number of pages5
JournalNew Microbiologica
Issue number2
Publication statusPublished - 2014


  • Curvularia lunata
  • Itraconazole
  • Nasal polyposis
  • Rhinosinusitis

ASJC Scopus subject areas

  • Microbiology (medical)


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