Allergy-associated FcRβ is a molecular amplifier of IgE- and IgG- mediated in vivo responses

David Dombrowicz, Siqi Lin, Véronique Flamand, Anna T. Brini, Beverly H. Koller, Jean Pierre Kinet

Research output: Contribution to journalArticle

Abstract

A role for the Fc receptor β chain (FcRβ) in the pathogenesis of allergy has been suggested by genetic studies. FcRβ is a subunit common to the high-affinity IgE (FcεRI) and low-affinity IgG (FcγRIII) receptors, both of which contribute to the initiation of allergic reactions. Current in vitro data suggest that FcRβ can function as either a positive or negative regulator, leaving a mechanistic explanation for its association with the development of atopy unclear. To address this controversy, we have generated novel mouse models relevant to human Fc receptor function. Analysis of FcεRI- and FcγRIII-dependent responses in these mice provides unequivocal genetic evidence that FcRβ functions as an amplifier of early and late mast cell responses and, remarkably, in vivo anaphylactic responses.

Original languageEnglish
Pages (from-to)517-529
Number of pages13
JournalImmunity
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 1998

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Fingerprint Dive into the research topics of 'Allergy-associated FcRβ is a molecular amplifier of IgE- and IgG- mediated in vivo responses'. Together they form a unique fingerprint.

  • Cite this