Abstract
Cyclosporine is a powerful immunosuppressive agent utilized in transplantation. Amongst its side effects, anaphylactic reactions are rare, occuring in 0.1% of treated patients. We describe the case of a 13-year-old boy who presented an anaphylactic shock during his first intraveinous cyclosporine injection. The diagnosis was not immediatly made since oral cyclosporine was quickly introduced. Three weeks later, he experienced a second anaphylactic shock while intraveinous cyclosporine was introduced again because of a suspicion of intestinal occlusion. Skin prick tests to intraveinous cyclosporine were positive. We suggest the possibility of an IgE-dependent allergy to Cremophor EL, present in the intraveinous but not the oral form of cyclosporine and discuss the literature.
Translated title of the contribution | Allergy to intraveinous cyclosporine |
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Original language | French |
Pages (from-to) | 102-105 |
Number of pages | 4 |
Journal | Revue Francaise d'Allergologie et d'Immunologie Clinique |
Volume | 48 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 2008 |
Keywords
- Allergy
- Cremophor EL
- Cyclosporine
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine