Allium vegetable intake and gastric cancer

A case-control study and meta-analysis

Federica Turati, Claudio Pelucchi, Valentina Guercio, Carlo La Vecchia, Carlotta Galeone

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Scope: To provide new epidemiological data and summarize evidence on the association between allium vegetable intake and gastric cancer risk. Methods and results: Data were from an Italian case-control study including 230 cases and 547 controls. Odds ratios were derived using multiple logistic regression. We combined results from all published studies using random-effect models. In our case-control study, the odds ratios were 0.59 (95% confidence interval, CI, 0.25-1.41) for ≥2 portions of onion per week, 0.69 (95% CI, 0.41-1.15) for high garlic intake, and 0.70 (95% CI, 0.39-1.28) for frequent use of both onion and garlic. Besides our study, 22 case-control and four cohort studies were included in the meta-analyses (>10 000 cases). The pooled relative risks for the highest versus lowest intake category were 0.78 (95% CI, 0.67-0.91) for allium vegetables (ten case-control and four cohort studies), 0.60 (95% CI, 0.47-0.76) for garlic (12 case-control studies), and 0.55 (95% CI, 0.41-0.73) for onion (13 case-control studies). The pooled relative risk for high allium vegetable intake from the four cohorts was 1.02 (95% CI, 0.88-1.18). Conclusion: High allium vegetable consumption is likely to reduce gastric cancer risk. This evidence is derived mainly from case-control studies. Further data from large cohorts are desirable for conclusive confirmation.

Original languageEnglish
Pages (from-to)171-179
Number of pages9
JournalMolecular Nutrition and Food Research
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Allium
stomach neoplasms
vegetable consumption
case-control studies
meta-analysis
Vegetables
Stomach Neoplasms
Meta-Analysis
Case-Control Studies
Garlic
Onions
garlic
onions
relative risk
cohort studies
odds ratio
Cohort Studies
Odds Ratio
confidence interval
Logistic Models

Keywords

  • Allium vegetables
  • Diet
  • Garlic
  • Gastric cancer
  • Onion

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Medicine(all)

Cite this

Allium vegetable intake and gastric cancer : A case-control study and meta-analysis. / Turati, Federica; Pelucchi, Claudio; Guercio, Valentina; Vecchia, Carlo La; Galeone, Carlotta.

In: Molecular Nutrition and Food Research, Vol. 59, No. 1, 01.01.2015, p. 171-179.

Research output: Contribution to journalArticle

Turati, Federica ; Pelucchi, Claudio ; Guercio, Valentina ; Vecchia, Carlo La ; Galeone, Carlotta. / Allium vegetable intake and gastric cancer : A case-control study and meta-analysis. In: Molecular Nutrition and Food Research. 2015 ; Vol. 59, No. 1. pp. 171-179.
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