Allium vegetables and upper aerodigestive tract cancers: A meta-analysis of observational studies

Valentina Guercio, Federica Turati, Carlo La Vecchia, Carlotta Galeone, Alessandra Tavani

Research output: Contribution to journalArticle

Abstract

Scope: To provide updated quantitative overall estimations of the relation between total allium, garlic, and onion intake on the risk of cancer of the upper aerodigestive tract (UADT). Methods and results: We combined data of published observational studies (21 case-control and four cohort studies), using a meta-analytic approach and random effects models. The overall relative risks (RR) and 95% confidence intervals (CIs) for the squamous cell carcinoma of the UADT were 0.79 (95% CI 0.56-1.11) for total allium, 0.74 (95% CI 0.57-0.95) for garlic, and 0.72 (95% CI 0.57-0.91) for onion for the highest versus the lowest consumption. The inverse relation was apparently stronger in case-control studies (RR 0.56, 95% CI 0.38-0.83 for total allium), in Chinese studies (RR 0.67, 95% CI 0.45-0.98 for garlic intake), and for esophageal than for head and neck cancers. Apparently, there was no relation between allium vegetable intake and adenocarcinoma of the esophagus. Conclusion: We found a moderate inverse association between allium vegetable intake and the risk of squamous cell carcinoma of the UADT in case-control studies. The relation was unclear in cohort studies and for adenocarcinoma of the esophagus.

Original languageEnglish
Pages (from-to)212-222
Number of pages11
JournalMolecular Nutrition and Food Research
Volume60
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Allium
observational studies
meta-analysis
Vegetables
Observational Studies
Meta-Analysis
confidence interval
vegetables
Confidence Intervals
Garlic
neoplasms
relative risk
garlic
Neoplasms
Onions
vegetable consumption
squamous cell carcinoma
esophagus
adenocarcinoma
case-control studies

Keywords

  • Allium vegetables
  • Diet
  • Epidemiology
  • Squamous cell carcinoma
  • Upper aerodigestive tract cancer

ASJC Scopus subject areas

  • Food Science
  • Biotechnology

Cite this

Allium vegetables and upper aerodigestive tract cancers : A meta-analysis of observational studies. / Guercio, Valentina; Turati, Federica; La Vecchia, Carlo; Galeone, Carlotta; Tavani, Alessandra.

In: Molecular Nutrition and Food Research, Vol. 60, No. 1, 01.01.2016, p. 212-222.

Research output: Contribution to journalArticle

Guercio, Valentina ; Turati, Federica ; La Vecchia, Carlo ; Galeone, Carlotta ; Tavani, Alessandra. / Allium vegetables and upper aerodigestive tract cancers : A meta-analysis of observational studies. In: Molecular Nutrition and Food Research. 2016 ; Vol. 60, No. 1. pp. 212-222.
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