Alloantigen and microbial antigen-induced cellular immune responses: Inhibitory effect of four anti-HLA class II monoclonal antibodies

G. C. Spagnoli, C. Ausiello, C. Palma, M. Alessio, L. De Monte, C. U. Casciani

Research output: Contribution to journalArticle

Abstract

Four monoclonal antibodies (MAb's) directed against different epitopes of class II structures coded for by the human major histocompatibility complex (HLA), were studied to evaluate the relevance of these molecules on the control of different in vitro cell-mediated immune responses. Irrespective of the epitopes recognized, all MAb's tested exerted a powerful inhibitory effect on mixed lymphocyte cultures and on proliferation induced by microbial antigens. The generation of cytotoxic T lymphocytes and natural killer-like effectors also were inhibited by the addition of anti-HLA class II MAb in the cultures. The anti-HLA class II MAb provide a useful tool for the study of the in vitro immune response and eventually for therapeutic immunomodulation.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalDiagnostic and Clinical Immunology
Volume5
Issue number6
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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