Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus

Marinos Kallikourdis, Kristian G. Andersen, Katie A. Welch, Alexander G. Betz

Research output: Contribution to journalArticle

Abstract

Regulatory T cells play an essential role in preventing fetal rejection by the maternal immune system. Here we show that, based on the expression of CCR5, regulatory T cells can be divided into a highly suppressive CCR5+ and a far less suppressive CCR5- subpopulation, suggesting that the former represent the effector arm of regulatory T cells. Although regulatory T cells from CCR5-/- gene deletion mutants still suppress, they are less effective mediators of maternal-fetal tolerance. The accumulation of CCR5+ regulatory T cells at this site appears to be enhanced by alloantigen. This finding is in stark contrast to the systemic expansion of regulatory T cells during pregnancy, which appears to be alloantigen- independent. The fact that CCR5+ regulatory T cells preferentially accumulate in the gravid uterus and that expression of CCR5 on regulatory T cells can be induced by activation lead us to propose that CCR5 is responsible for the accumulation of those regulatory T cells that have been activated by paternal antigens.

Original languageEnglish
Pages (from-to)594-599
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number2
DOIs
Publication statusPublished - Jan 9 2007

Keywords

  • Chemokine receptor
  • Effector T cells
  • Pregnancy
  • Tolerance

ASJC Scopus subject areas

  • Genetics
  • General

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