Alloantigen recognition by two human natural killer cell clones is associated with HLA-C or a closely linked gene

M. Colonna, T. Spies, J. L. Strominger, E. Ciccone, A. Moretta, L. Moretta, D. Pende, O. Viale

Research output: Contribution to journalArticlepeer-review

Abstract

Human natural killer (NK) cells with the CD3- CD16+ phenotype recognize allospecificities on normal T-cell blasts. The NK-defined specificity 1 (NK- 1) is recessively inherited and has been mapped to the major histocompatibility complex between the complement gene cluster and HLA-A. A gene for NK-1, however, has not been identified. Here we demonstrate that NK- 1 and the recently defined NK specificity 2 (NK-2) are reciprocally associated with homozygosity for a diallelic polymorphism at amino acid positions 77 and 80 in the putative peptide-binding site of HLA-C (P <10-5). NK-cell recognition of allogeneic cells may, therefore, be controlled by HLA-C itself or by a closely linked gene(s), which dominantly prevents (resistance alleles) or recessively permits (susceptibility alleles) recognition of still-unknown target determinants.

Original languageEnglish
Pages (from-to)7983-7985
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number17
Publication statusPublished - 1992

ASJC Scopus subject areas

  • General
  • Genetics

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