Allocentric spatial learning and memory deficits in Down syndrome

Pamela Banta Lavenex, Mathilde Bostelmann, Catherine Brandner, Floriana Costanzo, Emilie Fragnière, Giuliana Klencklen, Pierre Lavenex, Deny Menghini, Stefano Vicari

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Studies have shown that persons with Down syndrome (DS) exhibit relatively poor language capacities, and impaired verbal and visuoperceptual memory, whereas their visuospatial memory capacities appear comparatively spared. Individuals with DS recall better where an object was previously seen than what object was previously seen. However, most of the evidence concerning preserved visuospatial memory comes from tabletop or computerized experiments which are biased toward testing egocentric (viewpoint-dependent) spatial representations. Accordingly, allocentric (viewpoint-independent) spatial learning and memory capacities may not be necessary to perform these tasks. Thus, in order to more fully characterize the spatial capacities of individuals with DS, allocentric processes underlying real-world navigation must also be investigated. We tested 20 participants with DS and 16 mental age-matched, typically developing (TD) children in a real-world, allocentric spatial (AS) memory task. During local cue (LC) trials, participants had to locate three rewards marked by local color cues, among 12 locations distributed in a 4 m × 4 m arena. During AS trials, participants had to locate the same three rewards, in absence of LCs, based on their relations to distal environmental cues. All TD participants chose rewarded locations in LC and AS trials at above chance level. In contrast, although all but one of the participants with DS exhibited a preference for the rewarded locations in LC trials, only 50% of participants with DS chose the rewarded locations at above chance level in AS trials. As a group, participants with DS performed worse than TD children on all measures of task performance. These findings demonstrate that individuals with DS are impaired at using an AS representation to learn and remember discrete locations in a controlled environment, suggesting persistent and pervasive deficits in hippocampus-dependent memory in DS.

Original languageEnglish
Article number62
JournalFrontiers in Psychology
Volume6
Issue numberFEB
DOIs
Publication statusPublished - 2015

Fingerprint

Memory Disorders
Down Syndrome
Cues
Reward
Spatial Learning
Spatial Memory
Controlled Environment
Task Performance and Analysis
Hippocampus
Language
Color

Keywords

  • Capacity
  • Episodic
  • Genetic disorder
  • Hippocampus
  • Memory
  • Resolution

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Allocentric spatial learning and memory deficits in Down syndrome. / Lavenex, Pamela Banta; Bostelmann, Mathilde; Brandner, Catherine; Costanzo, Floriana; Fragnière, Emilie; Klencklen, Giuliana; Lavenex, Pierre; Menghini, Deny; Vicari, Stefano.

In: Frontiers in Psychology, Vol. 6, No. FEB, 62, 2015.

Research output: Contribution to journalArticle

Lavenex, PB, Bostelmann, M, Brandner, C, Costanzo, F, Fragnière, E, Klencklen, G, Lavenex, P, Menghini, D & Vicari, S 2015, 'Allocentric spatial learning and memory deficits in Down syndrome', Frontiers in Psychology, vol. 6, no. FEB, 62. https://doi.org/10.3389/fpsyg.2015.00062
Lavenex, Pamela Banta ; Bostelmann, Mathilde ; Brandner, Catherine ; Costanzo, Floriana ; Fragnière, Emilie ; Klencklen, Giuliana ; Lavenex, Pierre ; Menghini, Deny ; Vicari, Stefano. / Allocentric spatial learning and memory deficits in Down syndrome. In: Frontiers in Psychology. 2015 ; Vol. 6, No. FEB.
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