Allodynia in different forms of migraine

Carlo Lovati, D. D'Amico, S. Rosa, M. Suardelli, E. Mailland, P. Bertora, S. Pomati, C. Mariani, G. Bussone

Research output: Contribution to journalArticle


About 60% of patients complain of cutaneous allodynia during migraine episodes, often in the periorbitary region of the pain side. Pre-clinical studies have shown that the underlying mechanism is sensitisation of primary nociceptors and central trigeminovascular neurons and that patients have a lower pain threshold for mechanical stimulation compared to controls. The objective of this study was to determine the prevalence of allodynia during headache attacks in different forms of migraine. The subjects were 221 outpatients consecutively evaluated in the Headache Center of the L. Sacco Hospital in Milan: 114 had only attacks of migraine without aura (MO), 63 had also attacks with aura (MA) and 44 patients with chronic migraine with and without drug overuse (CM). Presence of head allodynia was investigated by a semistructured interview. Statistical analysis was performed by chi square test with Bonferroni correction for multiple comparisons. Forty-seven out of 114 MO patients (41.2%) complained of allodynia during headache episodes, 41 out of 63 MA patients (65.0%), and 29 out of 44 CM patients (65.9%). A higher frequency of allodynia in MA and CM with respect to MO patients was observed (p

Original languageEnglish
JournalNeurological Sciences
Issue numberSUPPL. 2
Publication statusPublished - May 2007


  • Allodynia
  • Aura
  • Chronic migraine
  • Migraine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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    Lovati, C., D'Amico, D., Rosa, S., Suardelli, M., Mailland, E., Bertora, P., Pomati, S., Mariani, C., & Bussone, G. (2007). Allodynia in different forms of migraine. Neurological Sciences, 28(SUPPL. 2).