Allogeneic cell transplant expands bone marrow distribution by colonizing previously abandoned areas: An FDG PET/CT analysis

Francesco Fiz, Cecilia Marini, Cristina Campi, Anna Maria Massone, Marina Podestà, Gianluca Bottoni, Roberta Piva, Francesca Bongioanni, Andrea Bacigalupo, Michele Piana, Gianmario Sambuceti, Francesco Frassoni

Research output: Contribution to journalArticle

Abstract

Mechanisms of hematopoietic reconstitution after bone marrow (BM) transplantation remain largely unknown.Weapplied acomputational quantification software application to hybrid 18F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) images to assess activity and distribution of the hematopoietic system throughout the whole skeleton of recently transplanted patients. Thirty-four patients underwent PET/CT 30 days after either adult stem cell transplantation (allogeneic cell transplantation [ACT]; n 518) or cord blood transplantation (CBT; n 516). Our software automatically recognized compact bone volume and trabecular bone volume (IBV) in CT slices. Within IBV, coregistered PET data were extracted to identify the active BM (ABM) from the inactive tissue. Patients were compared with 34 matched controls chosen among a published normalcy database. Whole body ABM increased in ACT and CBT when compared with controls (12.4 ± 3 and 12.8 ± 6.8 vs 8.1 ± 2.6 mL/kg of ideal body weight [IBW], P

Original languageEnglish
Pages (from-to)4095-4102
Number of pages8
JournalBlood
Volume125
Issue number26
DOIs
Publication statusPublished - Jun 25 2015

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ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology
  • Medicine(all)

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