Allogeneic hematopoietic stem cell transplantation for neuromyelitis optica

Raffaella Greco; Attilio Bondanza; Luca Vago; Lucia Moiola; Paolo Rossi; Roberto Furlan; Gianvito Martino; Marta Radaelli; Vittorio Martinelli; Maria Rosaria Carbone; Maria Teresa Lupo Stanghellini; Andrea Assanelli; Massimo Bernardi; Consuelo Corti; Jacopo Peccatori; Chiara Bonini; Paolo Vezzulli; Andrea Falini; Fabio Ciceri; Giancarlo Comi

doi:10.1002/ana.24079

Allogeneic hematopoietic stem cell transplantation for neuromyelitis optica

Raffaella Greco, Attilio Bondanza, Luca Vago, Lucia Moiola, Paolo Rossi, Roberto Furlan, Gianvito Martino, Marta Radaelli, Vittorio Martinelli, Maria Rosaria Carbone, Maria Teresa Lupo Stanghellini, Andrea Assanelli, Massimo Bernardi, Consuelo Corti, Jacopo Peccatori, Chiara Bonini, Paolo Vezzulli, Andrea Falini, Fabio Ciceri, Giancarlo Comi

Research output: Contribution to journal › Article › peer-review

Abstract

Neuromyelitis optica is a rare neurological autoimmune disorder characterized by a poor prognosis. Immunosuppression can halt disease progression, but some patients are refractory to multiple treatments, experiencing frequent relapses with accumulating disability. Here we report on durable clinical remissions after allogeneic hematopoietic stem cell transplantation in 2 patients suffering from severe forms of the disease. Immunological data evidenced disappearance of the pathogenic antibodies and regeneration of a naive immune system of donor origin. These findings correlated with evident clinical and radiological improvement in both patients, warranting extended clinical trials to investigate this promising therapeutic option. ANN NEUROL 2014;75:447-453

Original language	English
Pages (from-to)	447-453
Number of pages	7
Journal	Annals of Neurology
Volume	75
Issue number	3
DOIs	https://doi.org/10.1002/ana.24079
Publication status	Published - 2014

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Greco, R., Bondanza, A., Vago, L., Moiola, L., Rossi, P., Furlan, R., Martino, G., Radaelli, M., Martinelli, V., Carbone, M. R., Lupo Stanghellini, M. T., Assanelli, A., Bernardi, M., Corti, C., Peccatori, J., Bonini, C., Vezzulli, P., Falini, A., Ciceri, F., & Comi, G. (2014). Allogeneic hematopoietic stem cell transplantation for neuromyelitis optica. Annals of Neurology, 75(3), 447-453. https://doi.org/10.1002/ana.24079

Greco, R, Bondanza, A, Vago, L , Moiola, L, Rossi, P, Furlan, R , Martino, G, Radaelli, M, Martinelli, V, Carbone, MR, Lupo Stanghellini, MT, Assanelli, A, Bernardi, M, Corti, C, Peccatori, J , Bonini, C, Vezzulli, P, Falini, A, Ciceri, F & Comi, G 2014, 'Allogeneic hematopoietic stem cell transplantation for neuromyelitis optica', Annals of Neurology, vol. 75, no. 3, pp. 447-453. https://doi.org/10.1002/ana.24079

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abstract = "Neuromyelitis optica is a rare neurological autoimmune disorder characterized by a poor prognosis. Immunosuppression can halt disease progression, but some patients are refractory to multiple treatments, experiencing frequent relapses with accumulating disability. Here we report on durable clinical remissions after allogeneic hematopoietic stem cell transplantation in 2 patients suffering from severe forms of the disease. Immunological data evidenced disappearance of the pathogenic antibodies and regeneration of a naive immune system of donor origin. These findings correlated with evident clinical and radiological improvement in both patients, warranting extended clinical trials to investigate this promising therapeutic option. ANN NEUROL 2014;75:447-453",

author = "Raffaella Greco and Attilio Bondanza and Luca Vago and Lucia Moiola and Paolo Rossi and Roberto Furlan and Gianvito Martino and Marta Radaelli and Vittorio Martinelli and Carbone, {Maria Rosaria} and {Lupo Stanghellini}, {Maria Teresa} and Andrea Assanelli and Massimo Bernardi and Consuelo Corti and Jacopo Peccatori and Chiara Bonini and Paolo Vezzulli and Andrea Falini and Fabio Ciceri and Giancarlo Comi",

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AU - Greco, Raffaella

AU - Bondanza, Attilio

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AU - Moiola, Lucia

AU - Rossi, Paolo

AU - Furlan, Roberto

AU - Martino, Gianvito

AU - Radaelli, Marta

AU - Martinelli, Vittorio

AU - Carbone, Maria Rosaria

AU - Lupo Stanghellini, Maria Teresa

AU - Assanelli, Andrea

AU - Bernardi, Massimo

AU - Corti, Consuelo

AU - Peccatori, Jacopo

AU - Bonini, Chiara

AU - Vezzulli, Paolo

AU - Falini, Andrea

AU - Ciceri, Fabio

AU - Comi, Giancarlo

PY - 2014

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AB - Neuromyelitis optica is a rare neurological autoimmune disorder characterized by a poor prognosis. Immunosuppression can halt disease progression, but some patients are refractory to multiple treatments, experiencing frequent relapses with accumulating disability. Here we report on durable clinical remissions after allogeneic hematopoietic stem cell transplantation in 2 patients suffering from severe forms of the disease. Immunological data evidenced disappearance of the pathogenic antibodies and regeneration of a naive immune system of donor origin. These findings correlated with evident clinical and radiological improvement in both patients, warranting extended clinical trials to investigate this promising therapeutic option. ANN NEUROL 2014;75:447-453

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Allogeneic hematopoietic stem cell transplantation for neuromyelitis optica

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