Allogeneic hematopoietic stem cell transplantation for neuromyelitis optica

Raffaella Greco, Attilio Bondanza, Luca Vago, Lucia Moiola, Paolo Rossi, Roberto Furlan, Gianvito Martino, Marta Radaelli, Vittorio Martinelli, Maria Rosaria Carbone, Maria Teresa Lupo Stanghellini, Andrea Assanelli, Massimo Bernardi, Consuelo Corti, Jacopo Peccatori, Chiara Bonini, Paolo Vezzulli, Andrea Falini, Fabio Ciceri, Giancarlo Comi

Research output: Contribution to journalArticlepeer-review

Abstract

Neuromyelitis optica is a rare neurological autoimmune disorder characterized by a poor prognosis. Immunosuppression can halt disease progression, but some patients are refractory to multiple treatments, experiencing frequent relapses with accumulating disability. Here we report on durable clinical remissions after allogeneic hematopoietic stem cell transplantation in 2 patients suffering from severe forms of the disease. Immunological data evidenced disappearance of the pathogenic antibodies and regeneration of a naive immune system of donor origin. These findings correlated with evident clinical and radiological improvement in both patients, warranting extended clinical trials to investigate this promising therapeutic option. ANN NEUROL 2014;75:447-453

Original languageEnglish
Pages (from-to)447-453
Number of pages7
JournalAnnals of Neurology
Volume75
Issue number3
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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