Allogreffe de cellules souches hématopoïétiques et sujets âgés

Translated title of the contribution: Allogeneic hematopoietic stem cell transplantation in elderly

Luca Castagna, Didier Blaise, Sabine Furst

Research output: Contribution to journalArticlepeer-review

Abstract

Most of patients with hematological malignancies are elderly (more than 60 years). Allogeneic stem cell transplantation is an important and effective treatment for most of these diseases. However, the toxicity and the supposed frailty of elderly patients, have limited the applicability of allogeneic transplantation for these patients. Elderly patients are at high risk to develop life-threatening complications, if allogeneic transplantation is performed with myeloablative conditioning regimens and using bone marrow stem source. Since more than 10 years, reduced intensity conditioning regimen have been developed, allowing to overcome the age as contra-indication for allogeneic transplantation. On the other hand, it is the presence of comorbidities which identify frail patients. For these subjects, allogeneic transplantation should be not indicated. Furthermore, advances in the supportive care and the development of new molecules could allow to reduce the toxicity of myeloablative conditioning regimens and thus to offer more intensive regimens before transplantation also in elderly population.

Translated title of the contributionAllogeneic hematopoietic stem cell transplantation in elderly
Original languageFrench
Pages (from-to)915-925
Number of pages11
JournalBulletin du Cancer
Volume98
Issue number8
DOIs
Publication statusPublished - Aug 2011

Keywords

  • Allogeneic transplantation
  • Elderly
  • Reduced intensity regimens

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging
  • Hematology

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