We report on 2 patients affected by both celiac disease (CD) and β-thalassemia major who underwent successful myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for the latter condition. After HSCT, the introduction of a gluten-containing diet did not cause the reappearance of clinical, serological, and histological markers of CD in up to 5 years of follow-up. After transplantation, in both patients, dendritic cells and regulatory FoxP3T cells showed a recovery of normal values and no proliferative T-cell response upon gliadin stimulation was found. These data suggest that allogeneic HSCT may lead to induction of gluten tolerance in patients with CD.
|Number of pages||6|
|Journal||Journal of Pediatric Gastroenterology and Nutrition|
|Publication status||Published - Apr 2013|
- celiac disease
- hematopoietic stem cell transplantation
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health