Allogeneic hematopoietic stem cell transplantation may restore gluten tolerance in patients with celiac disease

Rachele Ciccocioppo, Maria Ester Bernardo, Maria Luisa Russo, Alessandro Vanoli, Carla Franco, Myriam Martinetti, Laura Catenacci, Giovanna Giorgiani, Marco Zecca, Antonio Piralla, Fausto Baldanti, Franco Locatelli, Gino Roberto Corazza

Research output: Contribution to journalArticlepeer-review

Abstract

We report on 2 patients affected by both celiac disease (CD) and β-thalassemia major who underwent successful myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for the latter condition. After HSCT, the introduction of a gluten-containing diet did not cause the reappearance of clinical, serological, and histological markers of CD in up to 5 years of follow-up. After transplantation, in both patients, dendritic cells and regulatory FoxP3T cells showed a recovery of normal values and no proliferative T-cell response upon gliadin stimulation was found. These data suggest that allogeneic HSCT may lead to induction of gluten tolerance in patients with CD.

Original languageEnglish
Pages (from-to)422-427
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume56
Issue number4
DOIs
Publication statusPublished - Apr 2013

Keywords

  • celiac disease
  • gluten
  • hematopoietic stem cell transplantation
  • tolerance

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

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