Allogeneic hemopoietic stem cell transplantation in solid tumors

Research output: Contribution to journalArticle

Abstract

The existence of a graft versus tumor (GVT) effect of donor-derived T cells after allogeneic hematopoietic stem cell transplantation is well established as a critical component for the success of the procedure in several hematologic malignancies. Although it has been suggested that a GVT effect might also be generated in patients affected by refractory solid tumors, the morbidity of conventional allogeneic hematopoietic stem cell transplantation has limited its investigation in these diseases. Recently introduced allogeneic nonmyeloablative regimens have greatly decreased morbidity and mortality related to transplants which retain a powerful GVT. On this basis, it has become possible to explore the existence of alloreactivity toward solid tumors. The present article reviews the early clinical results of this novel immunotherapeutic approach for solid tumors.

Original languageEnglish
Pages (from-to)2664-2666
Number of pages3
JournalTransplantation Proceedings
Volume37
Issue number6
DOIs
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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