Allogeneic lethally irradiated cord blood mononuclear cells in no-option critical limb ischemia: A "box of rain"

Cesare Perotti, Vittorio Arici, Marila Cervio, Claudia Del Fante, Fabrizio Calliada, Massimiliano Gnecchi, Maria Chiara Ciuffreda, Luigia Scudeller, Antonio Bozzani, Franco Ragni, Gianluca Viarengo, Elisabetta Cervio, Attilio Odero, Carlo Alberto Redi

Research output: Contribution to journalArticlepeer-review

Abstract

Critical limb ischemia (CLI) is burdened by a 40% major amputation rate, and a 5-year life expectancy 2 pressure, ankle/brachial index, and contrast-enhanced ultrasonography), and histological demonstration of muscular tissue repair and capillary network expansion. If our approach will be confirmed, the huge number of CB units currently discarded might be redirected toward regenerative medicine purposes, leading to cutting-edge solutions for important unmet clinical needs, such as ischemic diseases, which remain the main cause of disability and mortality in western countries.

Original languageEnglish
Pages (from-to)2806-2812
Number of pages7
JournalStem Cells and Development
Volume22
Issue number20
DOIs
Publication statusPublished - Oct 15 2013

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Hematology

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