TY - JOUR
T1 - Allogeneic marrow transplantation in patients with acute and chronic myeloid leukemia
T2 - Influence of total body irradiation dose and graft versus host disease on relapse rate
AU - Vitale, V.
AU - Corvo, R.
AU - Franzone, P.
AU - Frassoni, F.
AU - Scarpati, D.
AU - Barra, S.
AU - Van Lint, M. T.
PY - 1991
Y1 - 1991
N2 - From June 1981 to January 1988, 142 patients - 77 with acute myeloid leukemia (AML) and 65 with chronic myeloid leukemia (CML) - were treated with cyclophosphamide (60 mg/kg/d x 2 d) and total body irradiation (TBI) (9.90 Gy in 3 fractions in 3 d) before allogeneic bone marrow transplantation (BMT). All patients received marrow from an HLA identical sibling and were treated with cyclosporine A for graft versus host disease (GvHD) prophylaxis. An analysis of risk factors associated with leukemic relapse was carried out. A difference of ±18% between the calculated total dose TBI (9.90 Gy) and the actual dose measured (820-1250 cGy, mean 956 cGy) was observed and recorded according to in vivo measurements: 67 patients (36 AML and 31 CML) received
AB - From June 1981 to January 1988, 142 patients - 77 with acute myeloid leukemia (AML) and 65 with chronic myeloid leukemia (CML) - were treated with cyclophosphamide (60 mg/kg/d x 2 d) and total body irradiation (TBI) (9.90 Gy in 3 fractions in 3 d) before allogeneic bone marrow transplantation (BMT). All patients received marrow from an HLA identical sibling and were treated with cyclosporine A for graft versus host disease (GvHD) prophylaxis. An analysis of risk factors associated with leukemic relapse was carried out. A difference of ±18% between the calculated total dose TBI (9.90 Gy) and the actual dose measured (820-1250 cGy, mean 956 cGy) was observed and recorded according to in vivo measurements: 67 patients (36 AML and 31 CML) received
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M3 - Article
AN - SCOPUS:0026001321
VL - 78
SP - 207
EP - 216
JO - Bulletin du cancer. Radiotherapie : journal de la Societe francaise du cancer : organe de la societe francaise de radiotherapie oncologique
JF - Bulletin du cancer. Radiotherapie : journal de la Societe francaise du cancer : organe de la societe francaise de radiotherapie oncologique
SN - 0924-4212
IS - 3
ER -