Allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning in primary refractory prolymphocytic leukemia: Graft-versus-leukemia effect without graft-versus-host disease

L. Castagna, A. Nozza, A. Bertuzzi, L. Siracusano, I. Timofeeva, A. Santoro

Research output: Contribution to journalArticle

Abstract

A patient with progressive prolymphocytic leukemia (PLL) received an allogeneic stem cell transplant using a reduced intensity conditioning regimen to avoid prohibitive toxicities. Early in the post-transplant period, a high donor-derived CD8+ count was observed. One year from transplantation, the patient was in complete remission, fully donor chimeric and with a normal performance status, suggesting that this approach may represent a useful treatment option in patients with refractory PLL.

Original languageEnglish
Pages (from-to)1155-1156
Number of pages2
JournalBone Marrow Transplantation
Volume28
Issue number12
DOIs
Publication statusPublished - 2001

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Prolymphocytic Leukemia
Peripheral Blood Stem Cell Transplantation
Graft vs Host Disease
Leukemia
Transplants
Tissue Donors
Stem Cells
Transplantation
Therapeutics

Keywords

  • Allogeneic stem cell transplantation
  • Nonmyeloablative conditioning regimen
  • Prolymphocytic leukemia

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

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AU - Timofeeva, I.

AU - Santoro, A.

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