Allogeneic stem cell transplantation following reduced-intensity conditioning can induce durable clinical and molecular remissions in relapsed lymphomas: Pre-transplant disease status and histotype heavily influence outcome

P. Corradini, A. Dodero, L. Farina, R. Fanin, F. Patriarca, R. Miceli, P. Matteucci, M. Bregni, R. Scimè, F. Narni, E. Pogliani, A. Locasciulli, R. Milani, C. Carniti, A. Bacigalupo, A. Rambaldi, F. Bonifazi, A. Olivieri, A. M. Gianni, C. Tarella

Research output: Contribution to journalArticle

Abstract

The safety and efficacy of reduced-intensity conditioning (RIC) followed by allogeneic stem cell transplantation (SCT) for relapsed lymphomas remains unresolved. We conducted a prospective, multicentered, phase II trial. A total of 170 relapsed/refractory lymphomas received a RIC regimen followed by SCT from sibling donors. The primary study end point was non-relapse mortality (NRM). Histologies were non-Hodgkin's lymphomas (NHL) (indolent (LG-NHL), n=63; aggressive (HG-NHL), n=61; mantle cell lymphoma (MCL), n=14) and Hodgkin's disease (HD, n=32). Median follow-up was 33 months (range, 12-82). The results show that frequencies were as follows: cumulative NRM at 3 years, 14%; acute and chronic graft-versus-host disease (GVHD) 35 and 52%, respectively; 3-year overall survival (OS), 69% for LG-NHL, 69% for HG-NHL, 45% for MCL and 32% for HD (P=0.058); and 3-year relapse incidence, 29, 31, 35 and 81%, respectively (P

Original languageEnglish
Pages (from-to)2316-2323
Number of pages8
JournalLeukemia
Volume21
Issue number11
DOIs
Publication statusPublished - Nov 2007

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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