Allogeneic stem cell transplantation for advanced acute promyelocytic leukemia in the ATRA and ATO era

Safaa M. Ramadan, Ambra Di Veroli, Agnese Camboni, Massimo Breccia, Anna Paola Iori, Franco Aversa, Luca Cupelli, Cristina Papayannidis, Andrea Bacigalupo, William Arcese, Francesco Lo-Coco

Research output: Contribution to journalArticle

Abstract

The role of allogeneic stem cell transplant in advanced acute promyelocytic leukemia patients who received standard first- and second-line therapy is still unknown. We report the outcome of 31 acute promyelocytic leukemia patients (median age 39 years) who underwent allogeneic transplant in second remission (n=15) or beyond (n=16). Sixteen patients were real-time polymerase chain reaction positive and 15 negative for PML/RARA pre-transplant. The 4-year overall survival was 62% and 31% for patients transplanted in second remission and beyond, respectively (P=0.05), and 64% and 27% for patients with pre-transplant negative and positive real-time polymerase chain reaction, respectively (P=0.03). The 4-year cumulative incidence of relapse was 32% and 44% for patients transplanted in second remission and beyond, respectively (P=0.37), and 30% and 47% for patients transplanted with negative and positive real-time polymerase chain reaction, respectively (P=0.30). Transplantrelated mortality was 19.6%. In conclusion, allogeneic transplant is effective in advanced acute promyelocytic leukemia in the all-trans-retinoic acid and arsenic trioxide era, and should be considered once relapse is diagnosed.

Original languageEnglish
Pages (from-to)1731-1735
Number of pages5
JournalHaematologica
Volume97
Issue number11
DOIs
Publication statusPublished - Nov 1 2012

Keywords

  • Acute promyelocytic leukemia
  • Acute promyelocytic leukemia relapse
  • Allogeneic stem cell transplant
  • Alltrans retinoic acid
  • Arsenic trioxide

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Ramadan, S. M., Veroli, A. D., Camboni, A., Breccia, M., Iori, A. P., Aversa, F., Cupelli, L., Papayannidis, C., Bacigalupo, A., Arcese, W., & Lo-Coco, F. (2012). Allogeneic stem cell transplantation for advanced acute promyelocytic leukemia in the ATRA and ATO era. Haematologica, 97(11), 1731-1735. https://doi.org/10.3324/haematol.2012.065714