Allogeneic transplantation for Hodgkin's lymphoma

Research output: Contribution to journalArticle

Abstract

Summary: Hodgkin's lymphoma (HL) can be cured in most of the patients, but in case of refractory disease or relapse after autologous stem cell transplantation (SCT) the prognosis becomes very poor. In these patients a consensus about the standard approach has not been achieved so far and only allogeneic SCT has shown a long-term disease control. The postulated graft-versus-Hodgkin's lymphoma is a matter of controversy, but the clinical responses observed after donor lymphocyte infusions may explain the superiority of alloSCT over standard chemo-radiotherapy. The results of conventional myeloablative alloSCT had a relevant non-relapse mortality (NRM), discouraging its widespread application as salvage treatment. In the last 10 years, reduced intensity conditioning (RIC) significantly decreased the NRM, widening the application of alloSCT also to heavily pretreated patients. Taking into account all phase II studies, 20-30% of patients receiving RIC alloSCT are disease-free and probably some of them are cured.

Original languageEnglish
Pages (from-to)261-272
Number of pages12
JournalBritish Journal of Haematology
Volume152
Issue number3
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Allogeneic
  • Hodgkin's lymphoma
  • Reduced-intensity

ASJC Scopus subject areas

  • Hematology

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