Allopregnanolone and dehydroepiandrosterone response to corticotropin-releasing factor in patients suffering from Alzheimer's disease and vascular dementia

Francesca Bernardi, Antonio Lanzone, Rosa M. Cento, Rosario S. Spada, Ilaria Pezzani, Alessandro David Genazzani, Stefano Luisi, Michele Luisi, Felice Petraglia, Andrea Riccardo Genazzani

Research output: Contribution to journalArticle

Abstract

Objective: Neurosteroids have been suggested to be involved in the regulation of cognitive performances. A major neurosteroid gamma-aminobutyric acid (GABA) agonist is allopregnanolone: the main source of circulating allopregnanolone is the adrenal cortex. Studies indicated that a disturbance of the central regulation of the hypothalamic-pituitary-adrenocortical axis occurs in both senile (Alzheimer's disease: AD) and vascular dementia (VD). Design: The aim of the present study was to evaluate the levels of circulating allopregnanolone, dehydroepiandrosterone (DHEA) and cortisol and their response to corticotropin-releasing factor (CRF) test in AD and VD. Methods: Three groups of 12 subjects were included in the study: AD, VD and age-matched control subjects. CRF test was performed in all subjects and allopregnanolone, DHEA and cortisol levels were measured every 15 min for 2 h. Results: Mean ± S.E.M. allopregnanolone and DHEA basal levels were significantly lower in AD and VD than in controls, while cortisol levels were significantly higher than in controls (P

Original languageEnglish
Pages (from-to)466-471
Number of pages6
JournalEuropean Journal of Endocrinology
Volume142
Issue number5
Publication statusPublished - May 2000

ASJC Scopus subject areas

  • Endocrinology

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    Bernardi, F., Lanzone, A., Cento, R. M., Spada, R. S., Pezzani, I., Genazzani, A. D., Luisi, S., Luisi, M., Petraglia, F., & Genazzani, A. R. (2000). Allopregnanolone and dehydroepiandrosterone response to corticotropin-releasing factor in patients suffering from Alzheimer's disease and vascular dementia. European Journal of Endocrinology, 142(5), 466-471.