Allopurinol and superoxide dismutase administration in prevention of rat kidney ischemic injury

R. Rosati, F. Stortoni, V. Filingeri, F. Svegliati, V. Cervelli, C. U. Casciani

Research output: Contribution to journalArticle

Abstract

Preservation of renal function during warm ischemia has been an important issue in renal transplantation. In fact, human cadaver kidneys may be damaged during the period of warm ischemia preceding transplantation. Also, reperfusion is an important step in renal transplantation. During reperfusion of an ischemic organ, free oxygen radicals are formed that can induce renal damage. A simple means of ameliorating this damage could improve posttransplant function. The present study was designed to compare the efficacy of some drugs infused before occlusion of renal artery in preventing kidney injury, so that a longer duration of tissue ischemia can be tolerated in transplantation.

Original languageEnglish
Pages (from-to)928-930
Number of pages3
JournalTransplantation Proceedings
Volume20
Issue number5
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Rosati, R., Stortoni, F., Filingeri, V., Svegliati, F., Cervelli, V., & Casciani, C. U. (1988). Allopurinol and superoxide dismutase administration in prevention of rat kidney ischemic injury. Transplantation Proceedings, 20(5), 928-930.