Allosteric modulation of monomeric proteins

Paolo Ascenzi, Alessio Bocedi, Alessandro Bolli, Mauro Fasano, Stefania Notari, Fabio Polticelli

Research output: Contribution to journalArticle

Abstract

Multimeric proteins (e.g. hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric proteins (e.g. myoglobin) usually are assumed to be nonallosteric. However, the modulation of the functional properties of monomeric proteins by heterotropic allosteric effectors casts doubts on this assumption. Here, the allosteric properties of sperm whale myoglobin, human serum albumin, and human α-thrombin, generally considered as molecular models of monomeric proteins, are summarized.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalBiochemistry and Molecular Biology Education
Volume33
Issue number3
DOIs
Publication statusPublished - May 2005

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Keywords

  • Albumin
  • Allostery
  • Monomeric proteins
  • Myoglobin
  • Thrombin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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