Allosteric modulation of monomeric proteins

Paolo Ascenzi, Alessio Bocedi, Alessandro Bolli, Mauro Fasano, Stefania Notari, Fabio Polticelli

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Multimeric proteins (e.g. hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric proteins (e.g. myoglobin) usually are assumed to be nonallosteric. However, the modulation of the functional properties of monomeric proteins by heterotropic allosteric effectors casts doubts on this assumption. Here, the allosteric properties of sperm whale myoglobin, human serum albumin, and human α-thrombin, generally considered as molecular models of monomeric proteins, are summarized.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalBiochemistry and Molecular Biology Education
Volume33
Issue number3
DOIs
Publication statusPublished - May 2005

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Modulation
Myoglobin
Proteins
Sperm Whale
Molecular Models
Serum Albumin
Thrombin
Hemoglobins
Enzymes

Keywords

  • Albumin
  • Allostery
  • Monomeric proteins
  • Myoglobin
  • Thrombin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Allosteric modulation of monomeric proteins. / Ascenzi, Paolo; Bocedi, Alessio; Bolli, Alessandro; Fasano, Mauro; Notari, Stefania; Polticelli, Fabio.

In: Biochemistry and Molecular Biology Education, Vol. 33, No. 3, 05.2005, p. 169-176.

Research output: Contribution to journalArticle

Ascenzi, P, Bocedi, A, Bolli, A, Fasano, M, Notari, S & Polticelli, F 2005, 'Allosteric modulation of monomeric proteins', Biochemistry and Molecular Biology Education, vol. 33, no. 3, pp. 169-176. https://doi.org/10.1002/bmb.2005.494033032470
Ascenzi, Paolo ; Bocedi, Alessio ; Bolli, Alessandro ; Fasano, Mauro ; Notari, Stefania ; Polticelli, Fabio. / Allosteric modulation of monomeric proteins. In: Biochemistry and Molecular Biology Education. 2005 ; Vol. 33, No. 3. pp. 169-176.
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